中国现代医学杂志2026，Vol.36Issue(12)：1-6,6.DOI:10.3969/j.issn.1005-8982.2026.12.001
微创肺表面活性物质给药对新生儿呼吸窘迫综合征患儿血气指标及hs-CRP、PCT水平的影响
Effect of less invasive surfactant administration on blood gas parameters and levels of hs-CRP and PCT in neonates with respiratory distress syndrome
摘要
Abstract
Objective To explore the effects of less invasive surfactant administration(LISA)combined with nasal continuous positive airway pressure(nCPAP)on blood gas parameters and levels of high-sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)in neonates with respiratory distress syndrome(NRDS).Methods A retrospective analysis was conducted on the clinical data of 95 NRDS infants admitted to The First Affiliated Hospital of Wannan Medical University from January 2022 to December 2025.Based on the method of pulmonary surfactant(PS)administration,the patients were divided into the LISA group(n=55 cases,treated with LISA+nCPAP)and the intubation-surfactant-extubation(INSURE)group(n=40).Arterial partial pressure of oxygen(PaO2)and carbon dioxide(PaCO2)were measured before treatment(T0)and at 1 h(T1),6 h(T2),and 24 h(T3)after administration.Serum levels of hs-CRP and PCT were assessed at T0,T3,and 72 h after administration(T4).Clinical outcomes and the incidence of complications were also compared between the two groups.Results PaO2 and PaCO2 levels at T0,T1,T2,and T3 were analyzed using repeated-measures analysis of variance(ANOVA).The results showed that significant differences were observed across time points(F=165.324 and 212.542,respectively;both P=0.000)and between the two groups(F=12.455 and 18.676,respectively;both P=0.000),with higher PaO2 and lower PaCO2 in the LISA group than in the INSURE group.Significant differences were observed in the change trends of PaO2 and PaCO2 levels between the two groups(F=6.783 and 9.451,respectively;both P=0.000).Hs-CRP and PCT levels at T0,T3,and T4 were also analyzed using repeated-measures ANOVA.The results showed that significant differences were observed across time points(F=105.324 and 223.185,respectively;both P=0.000)and between the two groups(F=7.524 and 11.243,respectively;P=0.007 and 0.001),with lower hs-CRP and PCT levels in the LISA group.Significant differences were observed in the change trends of hs-CRP and PCT levels between the two groups(F=4.896 and 8.452,respectively;P=0.008 and 0.000).The duration of oxygen therapy and length of hospital stay were shorter in the LISA group than in the INSURE group(P＜0.05).In addition,the rates of recurrent need for mechanical ventilation and total complications were lower in the LISA group(P＜0.05).Conclusion LISA effectively improves blood gas parameters in pediatric patients and reduces hs-CRP and PCT levels,thereby lowering the incidence of recurrent need for mechanical ventilation and complications,as well as optimizing clinical outcomes.关键词
新生儿呼吸窘迫综合征/微创注入肺表面活性物质/血气指标/超敏C反应蛋白/降钙素原Key words
neonatal respiratory distress syndrome/less invasive surfactant administration/blood gas parameters/high-sensitivity C-reactive protein/procalcitonin分类
医药卫生引用本文复制引用
叶珍珍,陈广,贾妮旦,纪小艺,李志鸿..微创肺表面活性物质给药对新生儿呼吸窘迫综合征患儿血气指标及hs-CRP、PCT水平的影响[J].中国现代医学杂志,2026,36(12):1-6,6.基金项目
浙江省医院卫生科技计划项目(2024KY449) （2024KY449）
2025年皖南医学院校级质量工程重点项目(2025jyxm061) （2025jyxm061）
2024年皖南医学院第一附属医院人才引进项目(YR202423) （YR202423）
2024年皖南医学院第一附属医院三新项目(Y24031) （Y24031）
