中国现代医学杂志2026，Vol.36Issue(12)：14-19,6.DOI:10.3969/j.issn.1005-8982.2026.12.003
氮氧通气与氦氧通气在中重度急性呼吸窘迫综合征患者中应用效果的对比研究
Effects of nitrogen-oxygen ventilation versus heliox ventilation in patients with moderate-to-severe acute respiratory distress syndrome
摘要
Abstract
Objective To compare the effects of nitrogen-oxygen ventilation versus heliox ventilation in patients with moderate-to-severe acute respiratory distress syndrome(ARDS).Methods A total of 112 patients with moderate-to-severe ARDS admitted to the Longyan First Hospital Affiliated to Fujian Medical University between June 2023 and January 2025 were selected.Using a random number table,they were divided into a control group and an observation group,each comprising 56 patients.The control group received nitrogen-oxygen ventilation,whilst the observation group received heliox ventilation.The two groups were compared in terms of the duration of mechanical ventilation,total length of hospital stay,hospital costs,levels of inflammatory markers[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],blood gas parameters[partial pressure of carbon dioxide in arterial blood(PaCO2),partial pressure of oxygen in arterial blood(PaO2)],short-term prognosis(complications and the 28-day mortality rate).Results The duration of mechanical ventilation and the total length of hospital stay were shorter,and the hospital costs were lower in the observation group than in the control group(P＜0.05).Comparison of CRP,IL-6 and TNF-α levels in bronchoalveolar lavage fluid(BALF)between the observation group and the control group before mechanical ventilation and on days 1 and 3 of ventilation showed that there were statistically significant differences in CRP,IL-6 and TNF-α levels across the time points(P＜0.05)and between the groups(P＜0.05),with their levels in the observation group being lower than those in the control group.A comparison of the change trends of CRP,IL-6 and TNF-α levels in BALF between the observation group and the control group revealed statistically significant differences(P＜0.05).On day 3 of mechanical ventilation,PaCO2 in the observation group was lower than that in the control group,whilst PaO2 was higher in the observation group(P＜0.05).On day 3 of mechanical ventilation,PaCO2 was lower and PaO2 was higher in both groups compared with pre-ventilation values(P＜0.05).There was no statistically significant difference in the incidence of hypotension or hypoxemia between the observation group and the control group(P＞0.05).The 28-day mortality rate in the observation group was lower than that in the control group(P＜0.05).Conclusion Compared with nitrogen-oxygen ventilation,heliox ventilation effectively reduces airway pressure,alleviates pulmonary inflammatory responses,improves blood gas parameters,and lowers the 28-day mortality rate in patients with moderate-to-severe ARDS,resulting in better overall therapeutic outcomes.关键词
中重度急性呼吸窘迫综合征/氮氧通气/氦氧通气Key words
moderate-to-severe acute respiratory distress syndrome/nitrogen-oxygen ventilation/heliox ventilation分类
医药卫生引用本文复制引用
刘庭,李月红,赖小燕,李永顺,林胜阳,杜鑫杰..氮氧通气与氦氧通气在中重度急性呼吸窘迫综合征患者中应用效果的对比研究[J].中国现代医学杂志,2026,36(12):14-19,6.基金项目
福建省自然科学基金(2025J01318) （2025J01318）
龙岩市科技计划项目(2022LYF17100) （2022LYF17100）
