中国现代医学杂志2026，Vol.36Issue(12)：51-58,8.DOI:10.3969/j.issn.1005-8982.2026.12.008
肠道菌群-胆汁酸-FXR轴在代谢相关脂肪性肝病中的作用机制及治疗干预新进展
Mechanisms and therapeutic advances of the gut microbiota-bile acid-FXR axis in metabolic dysfunction-associated fatty liver disease
摘要
Abstract
Metabolic dysfunction-associated fatty liver disease(MAFLD)is a chronic liver condition closely linked to metabolic disorders and poses a serious threat to hepatic health and systemic metabolic balance.In recent years,the gut microbiota-bile acid-farnesoid X receptor(FXR)axis has emerged as a key regulatory network bridging intestinal microbial communities,bile acid metabolism,and host gut-liver crosstalk,and has become a research hotspot in MAFLD.The gut microbiota regulates FXR activity through microbial metabolites,bile acid composition,and signaling molecules,thereby influencing hepatic lipid synthesis,inflammatory responses,and fibrotic progression,and ultimately playing a critical role in the onset and progression of MAFLD.This review systematically summarizes the molecular mechanisms by which the gut microbiota-bile acid-FXR axis mediates gut-liver interaction,explores its role in the pathogenesis of MAFLD,and highlights recent advances in therapeutic interventions,aiming to provide a theoretical foundation for precision treatment and microbiota-targeted strategies in the management of MAFLD.关键词
代谢相关脂肪性肝病/肠道菌群/胆汁酸/FXR轴/作用机制/干预策略Key words
gut microbiota/bile acids/farnesoid X receptor axis/metabolic dysfunction-associated fatty liver disease/mechanisms/therapeutic strategies分类
医药卫生引用本文复制引用
潘雁,王红梅,何桥玲..肠道菌群-胆汁酸-FXR轴在代谢相关脂肪性肝病中的作用机制及治疗干预新进展[J].中国现代医学杂志,2026,36(12):51-58,8.基金项目
广东省自然科学基金(2023A1515011314) （2023A1515011314）
