中国畜牧兽医2026，Vol.53Issue(7)：3607-3618,12.DOI:10.16431/j.cnki.1671-7236.2026.07.018
乙酰辅酶A酰基转移酶2在动物脂肪代谢调节中的作用机制研究进展
Advances in the Mechanisms of Acetyl-CoA Acyltransferase 2 in the Regulation of Animal Fat Metabolism
摘要
Abstract
The metabolism of animal fats usually maintains a dynamic equilibrium within the body.Once this balance is disrupted,it may lead to lipid metabolism disorders,which can subsequently affect animal health by increasing the risk of metabolic diseases,inducing oxidative stress and chronic inflammation,and causing insulin resistance,among other pathways.One of the current efficient approaches is to regulate the expression levels of key factors involved in fat metabolism to change the direction of fat metabolism.Acetyl-CoA acyltransferase 2(ACAA2),as a key enzyme in the fatty acid catabolic pathway,catalyzes critical reactions during fatty acid β-oxidation and is crucial for maintaining the balance of fat metabolism.This article introduces the hazards of lipid metabolism disorders in animals and the regulatory factors,analyzes the biological functions,transcriptional regulation and post-translational modifications of ACAA2,and summarizes its roles and mechanisms in lipid metabolism regulation in animal liver tissues,adipose tissues and cardiovascular systems.Research on ACAA2 is expected to provide effective prevention and treatment strategies and theoretical basis for improving lipid metabolism disorders in animals and the associated series of metabolic diseases.关键词
动物/脂肪代谢/乙酰辅酶A酰基转移酶2(ACAA2)/作用机制Key words
animal/fat metabolism/acetyl-CoA acyltransferase 2(ACAA2)/mechanisms of action分类
农业科技引用本文复制引用
袁佳美,孙雯,唐奕霆,李梦瑶,胡建宏,胡英男,王梦洁,彭梦玲..乙酰辅酶A酰基转移酶2在动物脂肪代谢调节中的作用机制研究进展[J].中国畜牧兽医,2026,53(7):3607-3618,12.基金项目
安徽省自然科学基金青年项目(1908085QC144) （1908085QC144）
安徽省重点研究与开发计划项目(202004f06020008) （202004f06020008）
安徽省高等学校科学研究(自然科学类)重点项目(2022AH050930、2025AHGXZK31606) （自然科学类）
安徽省大学生创新创业训练计划项目(S202510364045、S202510364046) （S202510364045、S202510364046）
安徽农业大学大别山综合试验站产业联盟经费项目(CYLM2024-12) （CYLM2024-12）
