中国药房2026，Vol.37Issue(12)：1626-1630,5.DOI:10.6039/j.issn.1001-0408.2026.12.18
布托啡诺、尼卡地平、乌拉地尔和替罗非班经微量注射泵配伍给药的稳定性与相容性研究
Study on the stability and compatibility of butorphanol,nicardipine,urapidil and tirofiban administered via micro-infusion pump
摘要
Abstract
OBJECTIVE To investigate the stability and compatibility of butorphanol,nicardipine,urapidil,and tirofiban.METHODS A micro-infusion pump was used to simulate the infusion process.Samples were collected in real time from the needle tip at 0,2,4,6,and 8 h after mixing of the four drugs.The appearance,pH,and number of insoluble particles were examined.The contents of butorphanol,nicardipine,urapidil,and tirofiban were determined using the ultra-high-performance liquid chromatography method.RESULTS Within 8 hours,all mixed solutions remained clear and transparent,with no visible turbidity,precipitation,color change,or gas generation.The pH fluctuation ranged from 0.02 to 0.09,both within 0.1 pH units.The number of insoluble particles≥10 μm in size in each compatibility solution was≤9,and the number of insoluble particles≥25 μm was≤2,meeting the requirements of the 2025 edition of the Chinese Pharmacopoeia(Volume Ⅳ).The relative percentage contents of butorphanol,nicardipine,urapidil,and tirofiban at 8 hours after compatibility mixing ranged from 92.38%to 113.40%.CONCLUSIONS Within 8 hours under simulated clinical micro-infusion pump infusion conditions,the stability and compatibility of the mixed solution containing butorphanol,nicardipine,urapidil,and tirofiban were satisfactory.关键词
布托啡诺/尼卡地平/乌拉地尔/替罗非班/微量注射泵/联合输注/稳定性/相容性Key words
butorphanol/nicardipine/urapidil/tirofiban/micro-infusion pump/combined infusion/stability/compatibility分类
医药卫生引用本文复制引用
赵晓玉,段舒怡,安旭娜,张俐婷,范理菊,安静,董占军..布托啡诺、尼卡地平、乌拉地尔和替罗非班经微量注射泵配伍给药的稳定性与相容性研究[J].中国药房,2026,37(12):1626-1630,5.基金项目
河北省医学科学研究课题计划项目(No.20250307) （No.20250307）
吴阶平医学基金会临床科研专项资助基金(No.320.6750.2024-6-60) （No.320.6750.2024-6-60）
