中国药房2026，Vol.37Issue(12)：1648-1653,6.DOI:10.6039/j.issn.1001-0408.2026.12.22
基于肿瘤微环境探讨中药干预结直肠癌转移的研究进展
Research progress on traditional Chinese medicine interventions in colorectal cancer metastasis based on tumor microenvironment
摘要
Abstract
Colorectal cancer has an insidious onset,and some patients have already developed local invasion or metastasis at the time of diagnosis,which affects treatment strategy selection and survival prognosis.The tumor microenvironment is not only the basic condition for tumor cell survival but also the core regulatory factor driving their local invasion and distant metastasis.This article reviewed the mechanisms by which traditional Chinese medicine regulates the tumor microenvironment to inhibit colorectal cancer metastasis.It was found that traditional Chinese medicine active ingredients such as astragalus polysaccharides,leonurine,kaempferol,etc.,as well as traditional Chinese medicine formulas such as Jianpi jiedu formula,can inhibit colorectal cancer metastasis by regulating key links of the tumor microenvironment,including immunosuppression,inflammatory response,intestinal microecological disorder,abnormal angiogenesis,and extracellular matrix homeostasis imbalance.However,current related research was still mainly based on cell and animal experiments,with limited clinical evidence-based data,and mechanistic studies mostly focued on single signaling pathways.Future research should integrate multi-omics technologies and systems biology methods to systematically elucidate the key targets and action networks through which traditional Chinese medicine regulates the colorectal cancer tumor microenvironment to combat metastasis.关键词
结直肠癌/肿瘤转移/肿瘤微环境/中药活性成分/中药复方Key words
colorectal cancer/tumor metastasis/tumor microenvironment/traditional Chinese medicine active ingredients/traditional Chinese medicine formulas分类
医药卫生引用本文复制引用
王宇,张境怡,吴思雨,隋博文..基于肿瘤微环境探讨中药干预结直肠癌转移的研究进展[J].中国药房,2026,37(12):1648-1653,6.基金项目
国家科技重大专项(No.2025ZD0551700,No.2025ZD0551701) （No.2025ZD0551700,No.2025ZD0551701）
