中国医学装备2026，Vol.23Issue(6)：89-95,7.DOI:10.3969/j.issn.1672-8270.2026.06.017
基于可信样本溯源的生物医药研发数据共享框架研究
Framework of data sharing of biomedicine R&D on the basis of trusted sample traceability
摘要
Abstract
Objective:To construct a framework platform of data sharing of biomedicine research and development(R&D)on the basis of trusted sample traceability,so as to cope with the existed problems in collaborative sharing for data in biomedical R&D in the Yangtze River Delta region,and improve release efficiency of the value of data elements.Methods:The framework platform of data-sharing of biomedicine R&D of trusted sample traceability was constructed on the Blockchain technique.The traceability management about the full lifecycle circulation of biological sample was conducted,so as to ensure the authenticity and compliance of R&D data of derivative omics of that.It integrated three core systems included full-process traceability of sample,security management of data,and compliant application of data,which utilized intelligent contract to realize confirmation and certification of key operation,and combined data sandbox technique to realize"usable but invisible".The trusted circulation of tested samples with next-generation sequencing(NGS)of patients with non-small cell lung cancer was used as samples to verify the function of platform through prototype system of core function of platform.Results:The entire process,in which NGS testing samples of patients with non-small cell lung cancer were sent from hospital to an independent clinical laboratory(ICL)to complete test,and the data were ultimately used by science and research institution as compliance approach,demonstrated that this platform can significantly improve the transparency of the circulation process from biosample to relevant data.It can effectively ensure the compliance and traceability of data sharing,and form a closed-loop management system from sample circulation to data application.Conclusion:The framework platform of data sharing of biomedicine R&D based on trusted sample traceability can realize management for transparent traceability of full lifecycle of sample,and for safe controllability of data in full lifecycle,which can be used as effective approach of effective resolving difficult problem of data sharing of regional biomedicine R&D.关键词
区块链/可信样本溯源/数据共享/生物医药Key words
Blockchain/Trusted sample traceability/Data sharing/Biomedicine分类
医药卫生引用本文复制引用
曹青,廖芬,张佳颖,林靖生..基于可信样本溯源的生物医药研发数据共享框架研究[J].中国医学装备,2026,23(6):89-95,7.基金项目
上海市2023年度"科技创新行动计划"长三角科技创新共同体领域项目(23002440100)Shanghai 2023"Science and Technology Innovation Action Plan"Project in the Yangtze River Delta Science and Technology Innovation Community Field(23002440100) （23002440100）
