中国针灸2026，Vol.46Issue(6)：861-867,7.DOI:10.13703/j.0255-2930.20250718-0002
朱琏针灸兴奋法对缺血性脑卒中恢复期患者肢体功能及血清氧化应激指标、血管生成因子的影响
Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes,angiogenic factors in patients with ischemic stroke during the recovery period
摘要
Abstract
Objective To observe the effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes,and angiogenic factors in patients with ischemic stroke during the recovery period.Methods A total of 84 patients with ischemic stroke during the recovery period were randomly divided into a ZHU Lian acupuncture group(42 cases,5 cases dropped out)and a conventional acupuncture group(42 cases,8 cases dropped out).On the basis of routine treatment,the ZHU Lian acupuncture group received ZHU Lian's excitation-type acupuncture manipulation,while the conventional acupuncture group received conventional acupuncture treatment.Acupoints on the affected side were selected,including Fengchi(GB20),Jianyu(LI15),Quchi(LI11),Waiguan(TE5),Xinshe(Extra),Jianliao(TE14),Xinyi(Extra),Hegu(LI4),etc.Treatments were administered once daily for 3 weeks in both groups.The Fugl-Meyer assessment(FMA),Berg balance scale(BBS),modified Barthel index(MBI)scores and serum levels of superoxide dismutase(SOD),malondialdehyde(MDA),reduced glutathione(GSH),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),endothelin-1(ET-1)were observed before and after treatment in both groups.Results Compared with before treatment,the FMA,BBS,MBI scores and serum levels of SOD,GSH,VEGF,bFGF after treatment were increased in both groups(P＜0.001,P＜0.05,P＜0.01),and serum levels of MDA and ET-1 were decreased(P＜0.001);after treatment,the FMA,BBS,MBI scores and serum levels of SOD,GSH,VEGF,bFGF in the ZHU Lian acupuncture group were higher than those in the conventional acupuncture group(P＜0.05,P＜0.001),and serum levels of MDA and ET-1 in the ZHU Lian acupuncture group were lower than those in the conventional acupuncture group(P＜0.001,P＜0.01).Conclusion ZHU Lian's excitation-type acupuncture manipulation may exert neuroprotective effects in patients with ischemic stroke during the recovery period by modulating antioxidant capacity and angiogenesis,thereby improving limb function.关键词
缺血性脑卒中恢复期/朱琏针灸兴奋法/肢体功能/氧化应激/血管生成/随机对照试验Key words
ischemic stroke during the recovery period/ZHU Lian's excitation-type acupuncture manipulation/limb function/oxidative stress/angiogenesis/randomized controlled trial(RCT)引用本文复制引用
翟阳,梅小平,舒建龙,王瀚,高阳,黎芳,莫智珍,黄桂课,韦玉鲁,池腾飞,邹敏,庞延..朱琏针灸兴奋法对缺血性脑卒中恢复期患者肢体功能及血清氧化应激指标、血管生成因子的影响[J].中国针灸,2026,46(6):861-867,7.基金项目
广西自然科学基金资助项目:2024GXNSFAA010252、2025GXNSFBA069308 （）
2024年广西青年岐黄学者培养项目:GXQH202419 （）
2025年广西中医药适宜技术开发与推广项目:GZSY2025086 （）
2025年广西中医药大学联合基金项目:2025NN001 （）
广西壮族自治区中医药管理局自筹课题项目:GXZYA20230437 （）
