中国合理用药探索2026，Vol.23Issue(6)：38-43,6.DOI:10.3969/j.issn.2096-3327.2026.06.006
氨溴索联合乙酰半胱氨酸雾化吸入治疗小儿肺炎支原体肺炎合并支气管黏液栓的临床效果
Clinical Effect of Nebulized Ambroxol Combined with N-Acetylcysteine in Children with Mycoplasma pneumoniae Pneumonia Complicated by Bronchial Mucus Plugs
摘要
Abstract
Objective:To investigate the clinical effect of nebulized ambroxol(AMB)combined with N-acetylcysteine(NAC)in children with Mycoplasma pneumoniae pneumonia(MPP)complicated by bronchial mucus plugs.Methods:A total of 118 children with MPP complicated by bronchial mucus plugs admitted to our hospital from January 2023 to April 2025 were prospectively selected and randomized by the random number table method into a control group(nebulized NAC)and an observation group(nebulized AMB plus NAC),with 59 patients in each group.Changes in airway resistance indicators[airway resistance at 5 Hz(R5),airway resistance at 20 Hz(R20),and respiratory reactance at 5 Hz(X5)],serum inflammatory factors[interleukin-6(IL-6)and macrophage inflammatory protein-2(MIP-2)],and oxidative stress indicators[superoxide dismutase(SOD)and malondialdehyde(MDA)]before and after treatment were observed in the two groups.The time to symptom resolution,mucus plug clearance time,bronchoscopy intervention rate,and incidence of adverse reactions were compared between the two groups.Results:After treatment,R5,R20,IL-6,MIP-2,and MDA decreased in both groups and were lower in the observation group than in the control group(P<0.05),whereas X5 and SOD increased in both groups and were higher in the observation group than in the control group(P<0.05).The time to resolution of dyspnea and the mucus plug clearance time were shorter in the observation group than in the control group(P<0.05),and the bronchoscopy intervention rate was lower in the observation group(P<0.05).The overall incidence of adverse reactions did not differ significantly between the two groups(P>0.05).Conclusion:Nebulized NAC combined with AMB in children with MPP complicated by bronchial mucus plugs can further shorten mucus plug clearance time,reduce airway resistance,and help improve inflammatory and oxidative stress responses.关键词
肺炎支原体肺炎/支气管黏液栓/乙酰半胱氨酸/氨溴索/雾化Key words
Mycoplasma pneumoniae pneumonia/bronchial mucus plug/N-acetylcysteine/ambroxol/nebulization分类
医药卫生引用本文复制引用
杜颖,闫利霞,李国超,闫哲,夏婉蓉,张佳文..氨溴索联合乙酰半胱氨酸雾化吸入治疗小儿肺炎支原体肺炎合并支气管黏液栓的临床效果[J].中国合理用药探索,2026,23(6):38-43,6.基金项目
河南省医学科技攻关计划项目(LHGJ20192690) （LHGJ20192690）
