针灸和草药（英文）2026，Vol.6Issue(2)：155-187,33.DOI:10.1097/HM9.0000000000000200
天然血管舒张剂:在心血管疾病中的作用机制与治疗潜力
Natural vasodilators:mechanisms and therapeutic potential in cardiovascular diseases
摘要
Abstract
Natural products with vasodilatory properties are increasingly recognized for treating hypertension,angina,and heart failure owing to their efficacy,accessibility,and favorable safety profiles,rendering them viable therapeutic alternatives.Following a systematic search of the NCBI PubMed and CNKI databases,227 natural compounds with potent vasodilatory activity were identified.This review delineates the vasodilatory effects of major phytochemical classes-specifically flavonoids,saponins,phenols,and alkaloids-and evaluates preclinical evidence supporting their therapeutic application.Furthermore,potential vasodilatory mechanisms are elucidated,encompassing endothelium-dependent regulation of smooth muscle tone,fluid homeostasis,oxidative stress mitigation,and antagonism of the renin-angiotensin-aldosterone system.These mechanisms clarify the pharmacological basis of natural vasodilators,offering researchers and clinicians enhanced strategies for managing cardiovascular diseases.关键词
天然化合物/血管舒张/舒张因子/离子通道/肾素-血管紧张素-醛固酮系统/人参皂苷/小檗碱/白藜芦醇Key words
Natural products/Vasodilation/Vasodilatory factors/Ion Channel/RAAS/Ginsenosides/Berberine/Resveratrol引用本文复制引用
孙傲梅,Dake Qi,王启隆,Opoku Bonsu Francis,严舒桐,王静,赵皓爽,冷玲,黎瑞巧,刘洪涛,田晓轩..天然血管舒张剂:在心血管疾病中的作用机制与治疗潜力[J].针灸和草药（英文）,2026,6(2):155-187,33.基金项目
This study was supported by the National Key R&D Program of China(2022YFC3501800,2024YFC3505104),National Natural Science Foundation of China(No.82474310),and Key Laboratory of Chinese Medicinal Resource and Chinese Herbal Compound of the Ministry of Education Funding(KF2024001). （2022YFC3501800,2024YFC3505104）
