针灸临床杂志2026，Vol.42Issue(6)：95-100,6.DOI:10.19917/j.cnki.1005-0779.026115
针刺调控铁死亡干预帕金森病的研究进展
Research Progress on Acupuncture Intervention in PD via Regulation of Ferroptosis
摘要
Abstract
Ferroptosis is one of the pathogenic mechanisms underlying Parkinson's disease(PD)and plays a critical role in its onset and progression.Its pathological process involves disordered iron metabolism,oxidative stress,and mitochondrial dysfunction.In addition,ferroptosis may exacerbate the pathological aggregation ofα-synuclein and interact with neuroinflammation,thereby further aggravating the pathological progression of PD.Recent studies have shown that acupuncture may regulate ferroptosis by modulating iron metabolism,alleviating oxidative stress,promoting mitochondrial repair,improving neuroinflammation,and regulating ferroptosis-related signaling pathways,thereby protecting dopaminergic neurons and contributing to the prevention and treatment of PD.Therefore,this study reviews the relevant domestic and international literature and analyzes the effects and mechanisms of acupuncture intervention in PD from the perspective of ferroptosis,with the aim of providing references for future clinical and experimental research.关键词
帕金森/铁死亡/铁代谢/脂质过氧化/针刺Key words
Parkinson's disease/Ferroptosis/Iron metabolism/Lipid peroxidation/Acupuncture分类
医药卫生引用本文复制引用
陈霞,王顺,白妍,王玉琳,吕佩祝,刘世平,申一韦..针刺调控铁死亡干预帕金森病的研究进展[J].针灸临床杂志,2026,42(6):95-100,6.基金项目
国家自然科学基金面上项目(82474664) （82474664）
黑龙江省重点研发计划(2023ZX06C16). （2023ZX06C16）
