针灸临床杂志2026，Vol.42Issue(6)：106-111,6.DOI:10.19917/j.cnki.1005-0779.026117
电针治疗膀胱过度活动症的机制研究进展
Research Progress on EA Mechanism in Treating OAB
摘要
Abstract
The onset of overactive bladder(OAB)is closely associated with central regulatory dysfunction,peripheral nerve sensitization,and detrusor muscle dysfunction.Evidence suggests that electro-acupuncture(EA)can improve bladder sensory function and inhibit abnormal contractions by regulating the pontine micturition center and higher brain regions,suppressing the activity of C-fiber afferent pathways,and modulating autonomic nervous system balance as well as neurotransmitter release,including serotonin(5-HT),nitric oxide(NO),and adenosine triphosphate(ATP).In addition,EA may regulate ion channels in detrusor smooth muscle and exert anti-inflammatory effects.Current studies,however,mainly focus on single mechanisms,and understanding of multi-level network integration and optimal stimulation parameters remains limited.Future research should integrate neuroimaging and multi-omics approaches to further elucidate the multi-target regulatory mechanisms of EA and promote its precise clinical application.关键词
膀胱过度活动症/电针/中枢调控异常/逼尿肌功能障碍/抗炎Key words
Overactive bladder syndrome/Electro-acupuncture/Central regulatory dysfunction/Detrusor dysfunction/Anti-inflammation分类
医药卫生引用本文复制引用
邢曼,冯琦钒,张安冬..电针治疗膀胱过度活动症的机制研究进展[J].针灸临床杂志,2026,42(6):106-111,6.基金项目
国家自然科学基金地区项目(82260975) （82260975）
海南省卫生健康科技创新联合项目(WSJK2024MS219). （WSJK2024MS219）
