摘要
Abstract
Chimeric antigen receptor T-cell(CAR-T)therapy,a revolutionary technology in tumor immunotherapy,has achieved breakthrough progress in the treatment of hematological malignancies.To date,multiple CAR-T products have been approved for clinical use worldwide,but progress in their application to solid tumor treatment has been slow mainly due to the highly complex biological characteristics of solid tumors.In recent years,the continuous identification of novel targets in solid tumors,continuous innovations in genetic engineering technologies,growing maturity of combination therapeutic strategies,and rapid advancement in artificial intelligence have expanded the potential applications of CAR-T therapy in solid tumor treatment,highlighting its broad translational prospects.This article systematically reviews recent clinical progress in CAR-T therapy for solid tumors,comprehensively analyzes core challenges and corresponding countermeasures,and outlines future directions.关键词
实体瘤/CAR-T疗法/肿瘤相关抗原/肿瘤特异性抗原/肿瘤微环境/人工智能/临床研究Key words
Solid tumor/Chimeric antigen receptor T-cell therapy/Tumor-associated antigen/Tumor-specific antigen/Tumor microenvironment/Artificial intelligence/Clinical trial分类
医药卫生
