肿瘤防治研究2026，Vol.53Issue(6)：440-447,8.DOI:10.3971/j.issn.1000-8578.2026.25.0930
胸腔热灌注化疗在胸腔恶性肿瘤治疗中的应用进展
Progress of Hyperthermic Intrathoracic Chemotherapy in Treatment of Thoracic Malignant Tumors
盛津津 1晏菲 1马燕凌 1孙建海 1李黎1
作者信息
- 1. 430033 武汉,江汉大学附属湖北省第三人民医院肿瘤科
- 折叠
摘要
Abstract
Hyperthermic intrathoracic chemotherapy(HITHOC)is a localized treatment that combines hyperthermia with medications such as chemotherapy,anti-angiogenic agents,targeted therapy,or immun-otherapeutic agents.It has advanced clinical progress for conditions such as malignant pleural mesothelioma,pleural metastasis of lung cancer,and pleural dissemination of thymic tumors.Systematic analyses indicate that as an adjuvant therapy to cytoreductive surgery,HITHOC improves patient survival and effectively controls pleural effusion and pleural metastasis.It exerts antitumor effects by enhancing drug penetration through thermal effects,inducing apoptosis,and modulating the immune microenvironment.HITHOC combined with systemic therapies(e.g.,chemotherapy,targeted therapy,and immunotherapy)demonstrates synergistic potential,but its role as a local treatment should be clearly defined as adjunctive within the comprehensive management of advanced-stage patients.Further research is needed to clarify its indications,standardized protocols,and long-term efficacy and to explore optimized regimens and personalized combination treatment strategies.This review delves into the key bottlenecks hindering the development of hyperthermia therapy,such as the lack of high-level evidence-based medicine and the absence of standardized diagno-stic and efficacy evaluation criteria,and proposes potential solutions.关键词
胸腔热灌注化疗/胸腔恶性肿瘤/恶性胸膜间皮瘤/肺癌胸膜转移/联合治疗Key words
Hyperthermic intrathoracic chemotherapy/Thoracic malignant neo-plasm/Malignant pleural mesothelioma/Lung cancer pleural metastasis/Com-bination therapy分类
医药卫生引用本文复制引用
盛津津,晏菲,马燕凌,孙建海,李黎..胸腔热灌注化疗在胸腔恶性肿瘤治疗中的应用进展[J].肿瘤防治研究,2026,53(6):440-447,8.
