肿瘤防治研究2026，Vol.53Issue(6)：467-474,8.DOI:10.3971/j.issn.1000-8578.2026.25.0935
帕罗西汀与乳腺癌关联机制的多组学研究
Multi-omics Study on Mechanistic Association Between Paroxetine and Breast Cancer
摘要
Abstract
Objective To evaluate the association between paroxetine exposure and breast cancer risk by using a multi-omics approach and to elucidate the underlying molecular mechanisms.Methods A cross-sectional analysis was conducted using NHANES data from 2005 to 2016 to assess paroxetine exposure and breast cancer prevalence.Network pharmacology was employed to identify common targets and pathways,followed by Mendelian randomization analysis to validate causal relationships and molecular docking to further verify key interactions.Results Among 5 520 participants,paroxetine users showed a 270％increased risk of breast cancer after multivariate adjustment(adjusted OR=3.70,95％CI:1.15-11.99,P=0.032).Network pharmacology identified 92 overlapping targets,with mTOR emerging as a central hub(IVW OR=1.09,95％CI:1.06-1.13,P=6.67×10-7).Molecular docking confirmed a high-affinity binding between paroxetine and mTOR(binding energy:-8.3 kcal/mol).Pathway enrichment analysis indicated that the PI3K-Akt signaling pathway,endocrine resistance,and chemical carcinogenesis were key mechanisms.Conclusion Paroxetine use may be linked to an increased risk of breast cancer,possibly mediated through the mTOR pathway.关键词
帕罗西汀/乳腺癌/mTOR信号通路/网络药理学/孟德尔随机化Key words
Paroxetine/Breast cancer/mTOR signaling pathway/Network pharmacology/Mendelian randomization分类
医药卫生引用本文复制引用
靳光浩,杨甜甜,顾科..帕罗西汀与乳腺癌关联机制的多组学研究[J].肿瘤防治研究,2026,53(6):467-474,8.基金项目
Scientific Research Project of Wuxi Municipal Health Commission(Key Project)(No.Z202416) （Key Project）
Wuxi"Taihu Talent Plan"High-level Medical and Health Talents Project 无锡市卫生健康委员会科研项目(重大项目)(Z202416) （重大项目）
无锡市"太湖人才计划"医疗卫生高层次人才项目 （）
