肿瘤防治研究2026，Vol.53Issue(6)：492-498,7.DOI:10.3971/j.issn.1000-8578.2026.25.0982
免疫联合靶向治疗在MSS/pMMR型晚期结直肠癌中的研究进展
Research Progress of Immunotherapy Combined with Targeted Therapy in MSS/pMMR Advanced Colorectal Cancer
摘要
Abstract
Colorectal cancer(CRC)is a common malignant tumor.The treatment of patients with advanced disease still faces severe challenges.Among patients with metastatic colorectal cancer(mCRC),most of those with microsatellite stable(MSS)/proficient mismatch repair(pMMR)tumors are highly insensitive to monotherapy with immune checkpoint inhibitors.With in-depth investigations into the mechanisms of the tumor immune microenvironment in MSS/pMMR CRC,the combination strategies of immunotherapy and targeted therapy have become a key direction to break through the treatment bottleneck in this population.These strategies include combinations of immunotherapy with antiangiogenic agents,epidermal growth factor receptor inhibitors,histone deacetylase inhibitors,and MAPK pathway inhibitors.Although the current relevant evidence is mainly derived from early-phase clinical trials,a number of studies demonstrated that immunotherapy combined with targeted therapy can improve the objective response rate and survival benefit in patients with MSS/pMMR mCRC and shows remarkable efficacy advantages in specific subgroups.This article systematically reviews the biological basis and clinical research progress of relevant combination therapeutic strategies,discusses potential beneficiary subgroups,and prospects future research directions.It aims to provide theoretical evidence and clinical references for optimizing the individualized treatment paradigm for this large patient population.关键词
结直肠癌/免疫治疗/靶向治疗/微卫星稳定/错配修复功能完整Key words
Colorectal cancer/Immuno-therapy/Targeted therapy/Microsatell-ite stable/Proficient mismatch repair分类
医药卫生引用本文复制引用
黄金龙,路平,梁新军,魏少忠..免疫联合靶向治疗在MSS/pMMR型晚期结直肠癌中的研究进展[J].肿瘤防治研究,2026,53(6):492-498,7.基金项目
湖北省自然科学基金创新发展联合基金项目(2026AFC1224) （2026AFC1224）
湖北省卫健委重点支撑项目(WJ-2023Z011) （WJ-2023Z011）
湖北省肿瘤医院护航人才项目(2025HBC-HHHRC003) （2025HBC-HHHRC003）
湖北省肿瘤医院院内科研项目(2024HBC-HYN13,2025HBCHYN03) Project of Joint Fund for Innovation and Development of Natural Science Foundation of Hubei Province of China(No.2026AFC1224) （2024HBC-HYN13,2025HBCHYN03）
Health Commission of Hubei Province Scien-tific Research Project(No.WJ2023-Z011) （No.WJ2023-Z011）
Talent Project of Hubei Cancer Hospital(No.2025HBCHHHRC003) （No.2025HBCHHHRC003）
Scientific Research Projects of Hubei Cancer Hospital(No.2024HBCHYN13,2025HBCHYN03) （No.2024HBCHYN13,2025HBCHYN03）
