中外医学研究2026，Vol.24Issue(13)：146-152,7.DOI:10.14033/j.cnki.cfmr.2026.13.036
IL-22/STAT3信号通路在肠黏膜损伤修复中的作用及机制研究进展
Research Progress on the Role and Mechanisms of the IL-22/STAT3 Signaling Pathway in the Repair of Intestinal Mucosal Injury
摘要
Abstract
Intestinal mucosal injury is a common pathological manifestation of various intestinal disorders.Its occurrence can lead to increased permeability,bacterial translocation,and exacerbation of the disease.IL-22 is an important immunomodulatory factor that activates the STAT3 signaling pathway and plays a significant role in promoting the proliferation and differentiation of intestinal epithelial cells,inhibiting apoptosis,and maintaining intestinal barrier integrity.Although studies have indicated the involvement of the IL-22/STAT3 pathway in intestinal mucosal repair,the specific molecular mechanisms and complex signaling regulatory networks remain largely unclear.The study aims to systematically review recent research advances regarding this signaling pathway in intestinal mucosal repair,with a focus on its mechanisms in regulating cell proliferation,inflammatory responses,and maintaining barrier function.The goal is to provide theoretical references and potential therapeutic targets for the precise treatment of intestinal diseases and to promote further clinical research in this field.关键词
IL-22/STAT3信号通路/肠黏膜损伤/修复机制/肠道屏障Key words
IL-22/STAT3 signaling pathway/Intestinal mucosal injury/Repair mechanism/Intestinal barrier引用本文复制引用
苏文松,占凌辉..IL-22/STAT3信号通路在肠黏膜损伤修复中的作用及机制研究进展[J].中外医学研究,2026,24(13):146-152,7.基金项目
厦门市自然科学基金项目(3502Z20227352) （3502Z20227352）
