Abstract
Objective To investigate the clinical efficacy of early cardiac rehabilitation in patients with acute myocardial infarction(AMI)receiving aspirin after percutaneous coronary intervention(PCI),and to evaluate its impact on the rehabilitation quality.Methods A total of 110 AMI patients who underwent PCI at Suzhou Municipal Hospital from October 2023 to October 2025 were included in the study.According to the intervention mode actually received,the patients were allocated into a conventional group and a combined group,with 55 cases in each group.The conventional group received aspirin combined with routine rehabilitation guidance,while the combined group received early cardiac rehabilitation intervention in addition to these measures of the conventional group.The two groups were compared before and after intervention regarding the following parameters:flow-mediated dilation(FMD),endothelin-1(ET-1),angiotensin Ⅱ(Ang-Ⅱ),myocardial enzyme spectrum markers(creatine kinase[CK],creatine kinase isoenzyme-MB[CK-MB],and lactate dehydrogenase[LDH]),Coronary Heart Disease Self-Management Scale(CSMS)score,exercise tolerance,Barthel Index,6-min walking distance(6MWD),Somatic Symptom Scale(SSS)score,Chinese version of the Positive and Negative Affect Schedule(PANAS)score(positive affect[PA]and negative affect[NA]),coagulation parameters(thrombin time[TT],activated partial thromboplastin time[APTT],prothrombin time[PT],and fibrinogen[FIB]),Chinese Questionnaire of Quality of Life in Patients with Cardiovascular Diseases(CQQC)score,and the incidence of major adverse cardiovascular events(MACEs).Results After intervention,compared with the conventional group,the combined group showed increases in FMD score,CSMS score,exercise tolerance,Barthel Index,PA score,PT,APTT and TT levels,CQQC score,and 6MWD(P<0.05).In addition,the combined group showed decreases in ET-1,Ang-Ⅱ,CK,CK-MB,LDH,FIB levels,SSS and NA scores,and incidence of MACEs(P<0.05).Conclusion The implementation of aspirin combined with early cardiac rehabilitation intervention can improve the coagulation function,myocardial enzyme spectrum,somatic symptoms,and negative emotions in AMI patients after PCI,enhance their self-management ability and quality of life,and reduce the incidence of MACEs.It shows certain clinical application value.关键词
阿司匹林/早期心脏康复干预/AMI患者/PCI术后Key words
aspirin/early cardiac rehabilitation intervention/patients with acute myocardial infarction/period after PCI分类
医药卫生
