中医临床研究2026，Vol.18Issue(11)：143-148,6.DOI:10.3969/j.issn.1674-7860.2026.11.022
基于波形蛋白信号通路分析四妙散对肩周炎临床疗效提升及炎性反应的作用
The effect of Simiao San on scapulohumeral periarthritis and its influence on inflammatory response based on vimentin signaling pathway
摘要
Abstract
Objective:To analyze the effect of Simiao San(四妙散)in ameliorating inflammatory response and shoulder joint function of scapulohumeral periarthritis patients based on vimentin signaling pathway.Methods:A total of 160 scapulohumeral periarthritis patients who were treated in the Department of Traditional Chinese Medicine Orthopedics of the Second Affiliated Hospital of Guangzhou Medical University from May 2021 to December 2023 were selected and divided into the control group and the observation group,and they were given Meloxicam and Simiao San,respectively.After treatment,the visual analogue scale(VAS)score,European Shoulder Association CMS score,and the expression levels of shoulder joint vimentin and TGF-β1 were compared between the two groups.The fibroblast-like synovial cell lines cultured in vitro were grouped,and the expression levels of vimentin,TGF-β1,and hs-CRP in both groups were detected and compared.Results:Before treatment,there was no statistically significant difference in VAS scores of patients between the two groups in resting and exercise states(P＞0.05).After treatment,the VAS scores of patients in the observation group were lower than those in the control group(P＜0.05).Before treatment,there was no statistically significant difference in subjective and objective evaluation index scores of patients between the two groups(P＞0.05).After treatment,the CMS scores of patients in the observation group were significantly higher than those in the control group(P＜0.05).Before treatment,there were no statistically significant differences in the expression levels of vimentin,TGF-β1,and hs-CRP in the shoulder joint of patients between the two groups(P＞0.05).After treatment,the expression levels of vimentin,TGF-β1,and hs-CRP in the shoulder joint of patients in the observation group were lower than the control group(P＜0.05).The expression levels of vimentin,TGF-β1,and hs-CRP in the other groups were all lower than the control group(P＜0.05).It showed that the higher the dosage of Simiao San,the lower the expression levels of vimentin,TGF-β1 and hs-CRP(P＜0.05).There were no significant differences in the expression levels of vimentin,TGF-β1,and hs-CRP between the vimentin inhibitor group and the JAK2 inhibitor group(P＞0.05).It showed that the when vimentin inhibitors were combined with Simiao San,the higher the application dose,the lower the expression levels of vimentin,TGF-β1 and hs-CRP(P＜0.05).Conclusion:Simiao San can alleviate inflammatory reactions and improve shoulder joint function of scapulohumeral periarthritis patients by inhibiting vimentin signaling pathway.关键词
波形蛋白信号通路/四妙散/肩周炎/炎性反应/肩关节功能Key words
Vimentin signaling pathway/Simiao San/Scapulohumeral periarthritis/Inflammatory response/Shoulder joint function分类
医药卫生引用本文复制引用
黄振勇,朱名豪,袁钰莹,谭永振..基于波形蛋白信号通路分析四妙散对肩周炎临床疗效提升及炎性反应的作用[J].中医临床研究,2026,18(11):143-148,6.基金项目
广州市三级名中医工作室建设项目(穗卫函[2023]77号) （穗卫函[2023]77号）
广州市中医药和中西医结合科技项目(NO.20212A011022). （NO.20212A011022）
