中药新药与临床药理2026，Vol.37Issue(6)：1163-1171,9.DOI:10.19378/j.issn.1003-9783.2026.06.018
防己地黄汤临床应用、药理作用、化学成分的研究进展及质量标志物预测
Research Progress on the Clinical Applications,Pharmacological Effects,and Chemical Components of Fangji Dihuang Decoction and Prediction of Its Quality Markers
摘要
Abstract
Fangji Dihuang Decoction,originating from the Jin Gui Yao Lve,possesses the effects of nourishing yin,cooling blood,dispelling wind,and unblocking meridians.It is indicated for conditions such as mania and limb pain caused by wind pathogen affecting the shaoyin meridian.Clinically,Fangji Dihuang Decoction is frequently used to treat systemic lupus erythematosus,the manic phase of bipolar disorder,and chronic nephritis,achieving satisfactory therapeutic outcomes.Studies have revealed that Fangji Dihuang Decoction primarily contains chemical components such as iridoid glycosides,alkaloids,flavonoids,coumarins,and triterpenes,exhibiting significant pharmacological effects including anti-inflammatory,renal protective,and neuroprotective activities.Research on quality marker prediction suggests that catalpol,tetrandrine,prim-O-glucosylcimifugin,cinnamaldehyde,and glycyrrhizic acid are candidate components with strong correlations between the intrinsic quality of Fangji Dihuang Decoction and its clinical efficacy.This article systematically summarizes the research progress on the clinical application,pharmacological effects,chemical constituents,and quality marker prediction of Fangji Dihuang Decoction,aiming to provide a theoretical basis for the standardized development and clinical promotion of this formula.关键词
防己地黄汤/临床应用/药理作用/化学成分/质量标志物Key words
Fangji Dihuang Decoction/clinical application/pharmacological effects/chemical constituents/quality markers分类
医药卫生引用本文复制引用
王仕方,张国松,阳涛,王灿坚..防己地黄汤临床应用、药理作用、化学成分的研究进展及质量标志物预测[J].中药新药与临床药理,2026,37(6):1163-1171,9.基金项目
国家自然科学基金项目(82360324) （82360324）
江西省"双千计划"创新领军人才长期(青年)项目(jxsq2023101090) （青年）
江西省自然科学基金项目(20244BAB28016) （20244BAB28016）
江西中医药大学博士科研启动基金项目(2021BSZR014). （2021BSZR014）
