遵义医科大学学报2026，Vol.49Issue(6)：628-634,7.
养阴抗瘤饮与化疗联合治疗中晚期肺癌的临床研究
Clinical study on the combination of Yangyin Kangliu Yin and chemotherapy in the treatment of middle and advanced lung cancer
摘要
Abstract
Objective This study investigated the clinical value of combining the Yin-nourishing and Tumor-in-hibiting Decoction with chemotherapy for the treatment of advanced lung cancer from an immunomodulatory per-spective.Methods A total of 60 patients with locally advanced or metastatic lung cancer admitted to the Depart-ment of Oncology at the Second Affiliated Hospital of Guizhou University of Chinese Medicine between September 2020 and January 2025 were enrolled.They were divided into control(n=30,receiving chemotherapy alone)and intervention(n=30,receiving chemotherapy plus Yangyin Kangliu Yin)groups.Both groups completed two treatment cycles.The objective response rate(ORR)and disease control rate(DCR)were compared.Pre-and post-treatment measurements were evaluated.Results(1)The ORR(46.7％)and DCR(93.3％)in the intervention group were slightly higher than those in the control group(36.7％and 80.0％),but the differences were not significant;The total TCM syndrome score in the intervention group after treatment(8.28±0.39)was lower than control group(11.32±0.36,P＜0.05).(2)Post-treatment,serum CEA(17.59±5.85)ng/ml and ProGRP(481.33±196.33)pg/ml levels in the intervention group were lower than those in the control group(42.70±21.05 and 579.33±270.47)pg/ml(P＜0.05).(3)After treatment,the intervention group had higher levels of peripheral blood CD3+T cells(945.24±112.96),CD4+T cells(636.01±56.50)and NK cells(328.99±35.17)were higher than those in the control group(579.43±96.62,354.29±85.04,and 189.70±32.18 cells/μl,P＜0.05).(4)The incidence of Grade 0 gastrointestinal reactions(46.7％)and Grade 0 bone marrow suppression(53.3％)in the intervention group was higher than that in the control group(16.7％and 20.0％,P＜0.05).(5)The proportion of patients in the intervention group who achieved a symp-tom-free state for cough,sputum,shortness of breath,and fatigue(36.7％,50.0％,73.3％,and 60.0％)was higher than that in the control group(20.0％,20.0％,46.7％,and 23.3％,P＜0.05).Conclusion Yin-nourishing and tumor-inhibiting decoction combined with chemotherapy can enhance immune function by upregu-lating peripheral blood CD3+T,CD4+T,and NK cells in patients with advanced lung cancer.This approach re-duces tumor burden,alleviates chemotherapy-related adverse reactions,and improves clinical symptoms,provi-ding an effective immunomodulatory treatment strategy for patients with advanced lung cancer.关键词
养阴抗瘤饮/中晚期肺癌/免疫功能/CD3+T细胞/CD4+T细胞/自然杀伤细胞/化疗减毒增效Key words
Yangyin Kangliu Yin/middle-advanced lung cancer/immune function/CD3+T cells/CD4+T cells/NK cells/chemotherapy attenuation and synergy分类
医药卫生引用本文复制引用
吴佳龙,成警花,冯丽,司维群,刘静,张琳,蔡晓菁,徐静..养阴抗瘤饮与化疗联合治疗中晚期肺癌的临床研究[J].遵义医科大学学报,2026,49(6):628-634,7.基金项目
贵州省卫生健康委科学技术基金资助项目(NO:gzwkj 2024-288) （NO:gzwkj 2024-288）
贵州省中医药管理局、民族医药科学技术研究课题(NO:QZYY-2015-019) （NO:QZYY-2015-019）
贵州省科学技术基金资助项目[NO:黔科合J字(2015)2018]. （2015）
