遵义医科大学学报2026，Vol.49Issue(6)：677-688,12.
生物标志物多模态检测:医学检验新方法的应用与研究进展
Multi-modal detection of biomarkers:applications and research advances in medical laboratory
摘要
Abstract
With the growing demand for precision medicine and point-of-care testing(POCT),traditional sin-gle-signal detection methods are progressively demonstrating limitations in their sensitivity,specificity,and anti-interference capability.Multi-modal detection,which generates multi-signal output using multi-signal platforms,has emerged as a significant developmental trend in the field of biosensing.This review first elucidates the funda-mental principles of multi-modal detection,as well as the strategies for designing signal orthogonality.It subse-quently concentrates on key functional materials and nanoprobes construction methods for achieving multisignal output.Then,it categorizes and summarizes application examples of multi-modal detection systems for the highly sensitive detection of single or multiple biomarkers.Finally,it provides a comprehensive analysis of the current challenges faced by multi-modal detection technologies,while also examining prospective future directions in-tegrating Multi-modal detection with AI-assisted signal analysis and wearable multimode sensing for diagnostics and therapeutic applications.This review seeks to provide theoretical insights and technical guidance for the de-velopment of efficient and reliable biomarker detection methods.关键词
多模态检测/即时检测/纳米材料/多重信号探针Key words
multi-modal detection/point-of-care testing/nanomaterials/multiple signal probes分类
医药卫生引用本文复制引用
施华华,曹汝菲,段晓雷..生物标志物多模态检测:医学检验新方法的应用与研究进展[J].遵义医科大学学报,2026,49(6):677-688,12.基金项目
国家自然科学基金资助项目(NO:82160409,82560415) （NO:82160409,82560415）
贵州省科技计划项目[NO:黔科合基础MS(2026)907]. （2026）
