中药药理与临床2026，Vol.42Issue(5)：33-41,58,10.
基于痰饮停聚哮喘模型及组分配伍探究葶苈大枣泻肺汤升降浮沉药性
Shengjiangfuchen Drug Property of Tingli Dazao Xiefei Decoction Based on Asthma Rat Model of Tanyintingju and Component Compatibility
摘要
Abstract
Objective:Using a Tanyintingju(痰饮停聚)asthma rat model,this study aimed to explore the Shengjiangfuchen(升降浮沉)drug property of Tingli Dazao Xiefei Decoction(葶苈大枣泻肺汤)through component compatibility,providing theoretical guidance for the clinical formulation and compatibility of Tinglizi(葶苈子).Meth-ods:Ninety male SD rats were randomly divided into normal control group,model control group,Tinglizi group(2.3 g/kg),Dazao(大枣)group(9.3 g/kg),Tingli Dazao Xiefei Decoction group(2.3 g/kg+9.3 g/kg),fatty oil component+Dazao group(0.7 g/kg+9.3 g/kg),oligosaccharide component+Dazao group(30.5 mg/kg+9.3 g/kg),flavonoside component+Dazao group(6.8 mg/kg+9.3 g/kg),and dexamethasone group(0.1 mg/kg).The Tanyintingju asthma model was established by sensitization with ovalbumin(OVA)and aluminum hydroxide gel ad-juvant,followed by OVA aerosol challenge.Indicators from five major systems closely related to the Shengjiangfuchen property,including respiratory,digestive,urinary,central nervous,and circulatory systems,were measured.Results:Com-pared with the normal control group,rats in the model control group had increased cough frequency and elevated lung in-flammatory factors(P<0.05 or P<0.01),decreased motilin,increased gastrin,and reduced urine volume(P<0.01).Compared with the model control group,Tinglizi and its components with the Chenjiang(沉降)property combined with Dazao significantly reduced cough and wheezing frequency(P<0.05 or P<0.01),decreased IL-4 levels(P<0.01),in-creased IFN-γ levels(P<0.01),increased motilin levels,decreased gastrin secretion(P<0.05 or P<0.01),and in-creased urine volume(P<0.05 or P<0.01).Conclusion:Tinglizi and its components with the Chenjiang property,when combined with Dazao,can resist the internal disease and the upward disease progression in Tanyintingju asthma rats through regulation of five major systems,and retain the overall Chenjiang drug property after compatibility.关键词
葶苈子/升降浮沉/药性/痰饮停聚/组分/配伍Key words
Tinglizi/Shengjiangfuchen/Drug properties/Tanyintingju引用本文复制引用
郑亚娟,袁培培,高丽媛,阮元,李潘营,陈祎,李赛菲,冯卫生,郑晓珂..基于痰饮停聚哮喘模型及组分配伍探究葶苈大枣泻肺汤升降浮沉药性[J].中药药理与临床,2026,42(5):33-41,58,10.基金项目
国家自然科学基金项目(编号:82405238) （编号:82405238）
国家重点研发计划-中医药现代化研究(编号:2019YFC1708802) （编号:2019YFC1708802）
河南省高层次人才特殊支持计划"中原千人计划"-中原领军人才(编号:ZYQR2018100) （编号:ZYQR2018100）
河南中医药大学博士科研基金资助项目(编号:RSBSJJ2018-04) （编号:RSBSJJ2018-04）
河南省科技攻关计划项目(编号:232102310452). （编号:232102310452）
