中药药理与临床2026，Vol.42Issue(5)：108-116,9.
化疗联合经典名方小柴胡汤治疗乳腺癌疗效及安全性的Meta分析
Meta-Analysis of Efficacy and Safety of Chemotherapy Combined with the Classic Prescription Xiaochaihu Decoction for Treating Breast Cancer
摘要
Abstract
Objective:To systematically evaluate the efficacy and safety of chemotherapy combined with the classic prescription Xiaochaihu(小柴胡)Decoction in the treatment of breast cancer by meta-analysis and provide evidence-based medical evidence support.Methods:Randomized controlled studies on chemotherapy combined with Xiaochaihu Decoction for treating breast cancer that were published before January 1,2026 were searched against PubMed,Embase,The Cochrane Library,Web of Science,CNKI,Wanfang Data,VIP,and SinoMed.RevMan5.3 was used for data analysis.Results:Seventeen studies were included,with 1 292 patients.The results of meta-analysis showed that compared with chemotherapy alone,chemotherapy combined with Xiaochaihu Decoction improved the clinical response rate[RR=1.45,95%CI(1.30,1.62),P<0.01],decreased the levels of carbohydrate antigen 125(CA125)[MD=-41.26,95%CI(-53.32,-29.20),P<0.01],carbohydrate antigen 153(CA153)[MD=-15.28,95%CI(-16.81,-13.75),P<0.01],carcinoembryonic antigen(CEA)[MD=-3.73,95%CI(-4.23,-3.24),P<0.01],insulin-like growth factor-1(IGF-1)[MD=-58.09,95%CI(-59.97,-56.21),P<0.01],and soluble E-cadherin(sEC)[MD=-0.79,95%CI(-0.82,-0.77),P<0.01],increased T lymphocytes(CD3+,CD4+,and CD4+/CD8+)[MD=0.31,95%CI(0.25,0.36),P<0.01],inhibited CD8+expression[MD=-5.88,95%CI(-6.52,-5.24),P<0.01],raised the levels of immunoglobulins A,M,and G[MD=0.50,95%CI(0.47,0.53),P<0.01],lowered the levels of tumor vascular endothelial growth factors A[MD=-6.98,95%CI(-8.68,-5.28),P<0.01]and B[MD=-5.82,95%CI(-7.73,-3.90),P<0.01],and alleviated adverse reactions after chemotherapy.Conclusion:Chemotherapy combined with Xiaochaihu Decoction in the treatment of breast cancer can improve the clinical response rate,elevate the levels of T lymphocytes and immunoglobulins,inhibit CD8+expression,lower the levels of tumor markers and tumor vascular endothelial growth factors,and reduce adverse re-actions.The conclusion remains to be validated by more high-quality,multi-center,and large-sample studies.关键词
小柴胡汤/化疗/乳腺癌/系统评价/Meta分析Key words
Xiaochaihu Decoction/Chemotherapy/Breast cancer/Systematic review/Meta-analysis引用本文复制引用
谢贞明,吴文宇,杨兵,罗莉,唐东昕..化疗联合经典名方小柴胡汤治疗乳腺癌疗效及安全性的Meta分析[J].中药药理与临床,2026,42(5):108-116,9.基金项目
贵州省高等学校中医药民族医药防治肿瘤医学转化工程研究中心(编号:黔教技[2023]037号) （编号:黔教技[2023]037号）
贵州省科技计划项目(编号:黔科合基础-ZK[2022]一般498、黔科合基础-ZK[2022]一般487、黔科合支撑[2021]一般095、黔科合平台人才[2020]5013) （编号:黔科合基础-ZK[2022]一般498、黔科合基础-ZK[2022]一般487、黔科合支撑[2021]一般095、黔科合平台人才[2020]5013）
贵州省中医肿瘤传承与科技创新人才基地(编号:黔人领发[2018]3号) （编号:黔人领发[2018]3号）
贵州省高层次创新型人才培养计划(百层次)(编号:黔科合人才(2016)4032号) （百层次）
中医肿瘤学研究生工作站(编号:黔教研合JYSZ字[2014]018). （编号:黔教研合JYSZ字[2014]018）
