中药药理与临床2026，Vol.42Issue(5)：141-151,11.
TNF-α相关炎症机制在绝经后骨质疏松症中的作用及中药活性成分、单味药、复方干预的研究进展
The Role of TNF-α-Related Inflammatory Mechanisms in Postmenopausal Osteoporosis and the Research Progress of Interventions with Active Components,Single Herbs,and Compound Formulas of Chinese Medicine
摘要
Abstract
Postmenopausal osteoporosis(PMOP)is the most common metabolic bone disease in middle-aged and elderly women,and its occurrence and progression are closely associated with inflammatory immune abnormalities induced by estrogen deficiency.With the development of osteoimmunology,tumor necrosis factor-α(TNF-α)has been recognized as an important proinflammatory cytokine linking immune activation to bone remodeling imbalance.Estrogen deficiency promotes aberrant activation of TNF-α through multilayered immune regulatory mechanisms and further enhances osteo-clast differentiation and bone resorption while suppressing osteoblast function through signaling pathways such as nuclear factor kappa B(NF-κB),Mitogen-activated protein kinase(MAPK),and phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),ultimately leading to bone remodeling imbalance.Meanwhile,TNF-α inhibitors have been shown to im-prove bone metabolic markers and increase bone mineral density in patients with inflammatory diseases;however,their long-term safety,economic burden,and benefits on fracture outcomes remain limited.Existing studies have shown that re-ductions in inflammatory factors such as TNF-α during traditional Chinese medicine(TCM)interventions for PMOP are often accompanied by improvements in bone metabolism,suggesting that TNF-α may be one of the important associated factors in the therapeutic effects of TCM.This review summarizes the role of TNF-α in the pathogenesis of PMOP and outlines the characteristics of TNF-α changes and the related signaling pathways during TCM interventions,with the aim of providing a theoretical reference for further elucidating the therapeutic mechanisms of TCM.关键词
绝经后骨质疏松症/中药/免疫炎症反应/骨重塑/肿瘤坏死因子-α/受体激活核因子κB/丝裂原激活蛋白激酶Key words
Postmenopausal osteoporosis/Traditional Chinese medicine/Immune inflammatory response/Bone remode-ling/Tumor necrosis factor-alpha(TNF-α)/Receptor-activated nuclear factor kappa B(NF-κB)/Mitogen-activated pro-tein kinase(MAPK)引用本文复制引用
陈雨慧,胡竟一,白筱璐,余悦,林雪燕,彭佳华,牛圆圆,雷玲,李东晓..TNF-α相关炎症机制在绝经后骨质疏松症中的作用及中药活性成分、单味药、复方干预的研究进展[J].中药药理与临床,2026,42(5):141-151,11.基金项目
四川省中医药科学院事业发展推进资金专项项目(编号:SYF-2025-1). （编号:SYF-2025-1）
