中医肿瘤学杂志2026，Vol.8Issue(3)：53-59,93,8.DOI:10.19811/j.cnki.ISSN2096-6628.2026.05.007
基于动态18F-FDG PET/CT探讨乳腺癌肝郁痰凝证与冲任失调证患者腋窝淋巴结代谢差异
Metabolic Differences in Axillary Lymph Nodes Between Breast Cancer Patients with Liver Depression and Phlegm Stagnation Syndrome and Chong-Ren Disharmony Syndrome Based on Dynamic 18F-FDG PET/CT
摘要
Abstract
Objective To explore the differences in 18F-FDG metabolic kinetics of axillary lymph nodes in breast cancer patients with liver depression and phlegm stagnation syndrome and those with Chong-Ren disharmony syndrome,and to investigate the clinical significance.Methods A total of 27 patients diagnosed with liver depression and phlegm stagnation syndrome or Chong-Ren disharmony syndrome were prospectively included.Dynamic PET/CT imaging was performed(continuous acquisition for 60 minutes after injection,and static scans at 90,120,and 150 minutes).Regions of interest were delineated for 91 axillary lymph nodes,and the maximum standardized uptake value(SUVmax)and mean standardized uptake value(SUVmean)at each time point were obtained.The differences in metabolic parameters between the two groups were compared.Results The age of patients in the Chong-Ren disharmony syndrome group was significantly higher than that in the liver depression and phlegm stagnation syndrome group[(59.82±8.05)years vs(44.38±7.91)years,P＜0.001].In the early time phase(1～10 minutes),SUVmax and SUVmean in the Chong-Ren disharmony syndrome group were significantly higher than those in the liver depression and phlegm stagnation syndrome group(P＜0.05);from 15 minutes onward,no significant differences were observed between the two groups.There were no statistically significant differences in the early uptake slope or standardized uptake values between the two groups.Age subgroup analysis showed that in patients≥50 years old,the peak time in the liver depression and phlegm stagnation syndrome group was later than that in the Chong-Ren disharmony syndrome group(P＜0.05).After controlling for age,the early metabolic differences between the two syndromes were no longer significant.Conclusion This study preliminarily suggests that the early metabolic differences in axillary lymph nodes between the Chong-Ren disharmony syndrome and liver depression and phlegm stagnation syndrome in breast cancer mainly originates from age,indicating a deep coupling between traditional Chinese medicine syndromes and physiological stages.关键词
乳腺肿瘤/肝郁痰凝证/冲任失调证/正电子发射断层显像/氟脱氧葡萄糖F18/年龄因素Key words
breast tumor/liver depression and phlegm stagnation syndrome/Chong-Ren disharmony syndrome/positron emission tomography/fluorodeoxyglucose F18/age factor分类
医药卫生引用本文复制引用
李圆,冯雅雯,杨少习,谢石文..基于动态18F-FDG PET/CT探讨乳腺癌肝郁痰凝证与冲任失调证患者腋窝淋巴结代谢差异[J].中医肿瘤学杂志,2026,8(3):53-59,93,8.基金项目
广东省中医药局基金(编号:20241108) （编号:20241108）
广东省医学基金(编号:B2023236). （编号:B2023236）
