摘要
Abstract
Chronic wounds have emerged as a global public health concern,characterized by prolonged disease course,poor prognosis,and significant patient healthcare burden.Debridement,as a critical step in wound bed preparation,directly determines therapeutic outcomes.Enzymatic debridement refers to the selective application of enzymatic agents to necrotic tissue for targeted debridement.Among these,collagenase-based preparations are the most widely used and evidence-supported enzymatic debridement agents in clinical practice.They selectively degrade necrotic collagen without damaging healthy tissue,while also exerting multiple effects such as anti-inflammatory action,modulation of the wound microenvironment,promotion of granulation tissue formation,and enhancement of epithelialization.This article systematically reviews the historical development of enzymatic debridement,summarizes the mechanisms of collagenase-based preparations,and evaluates their clinical applications in burn wounds,diabetic foot ulcers,pressure ulcers,and vascular occlusive wounds.Furthermore,it provides insights based on the latest guidelines and research advancements to support standardized clinical practice.关键词
酶学清创/胶原酶制剂/创面愈合/烧伤/糖尿病足溃疡/压力性溃疡/血管闭塞性创面/创面微环境Key words
Enzymatic debridement/Collagenase-based preparations/Wound healing/Burns/Diabetic foot ulcers/Pressure ulcers/Vascular occlusive wounds/Wound microenvironment分类
医药卫生
