组织工程与重建外科杂志2026，Vol.22Issue(3)：245-251,7.DOI:10.3969/j.issn.1673-0364.2026.03.002
胫骨横向骨搬移联合胶原酶治疗难愈性糖尿病足溃疡
Tibial transverse transport combined with collagenase therapy for refractory diabetic foot ulcers
刘宁 1宋扬 1崔新涛 1侯冬玉 1曲锶晗 1赵震宇1
作者信息
- 1. 150086 黑龙江省哈尔滨市 哈尔滨医科大学附属第二医院烧伤与创面修复外科
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of tibial transverse transport(TTT)combined with collagenase in the treatment of refractory diabetic foot ulcers.Methods A retrospective analysis was conducted on 40 patients with refractory diabetic foot ulcers who met the inclusion criteria and were admitted between September 2021 and September 2023.The 40 patients were divided into two groups:the collagenase group(22 patients)received treatment with TTT combined with collagenase ointment,while the non-collagenase group(18 patients)received TTT treatment alone.The clinical efficacy,follow-up results and auxiliary examination findings were compared between the two groups.Results The hospitalization time,antibiotic usage time,wound dressing frequency,and the reduction rate of wound area upon discharge in the collagenase group were all better than those in the non-collagenase group(P<0.05).During the follow-up period,the wound healing time in the collagenase group was shorter than that in the non-collagenase group(P<0.05).One week after surgery and one month after surgery,the WBC,CRP,and ESR in the collagenase group were all better than those in the non-collagenase group(P<0.05).Conclusion The combination of TTT technology and collagenase for the treatment of refractory diabetic foot ulcers can improve distal limb blood supply while ensuring thorough debridement,thereby shortening treatment duration and reducing recurrence rates.关键词
糖尿病足/胫骨横向骨搬移/胶原酶/血运重建Key words
Diabetic foot/Tibial transverse transport/Collagenase/Revascularization分类
医药卫生引用本文复制引用
刘宁,宋扬,崔新涛,侯冬玉,曲锶晗,赵震宇..胫骨横向骨搬移联合胶原酶治疗难愈性糖尿病足溃疡[J].组织工程与重建外科杂志,2026,22(3):245-251,7.
