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Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation

Ziyu Le Haojiong Zhang Li Chen Wanzun Lin Qingting Huang Shikai Geng Wei Hu Huaiyuan Chen Fangzhu Wan Xingyu Liu Jiyi Hu Fengtao Su Jiade JLu Lin Kong

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(3)：P.595-609,15.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(3)：P.595-609,15.DOI:10.3724/abbs.2025130

Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation

Ziyu Le ¹Haojiong Zhang ¹Li Chen ¹Wanzun Lin ¹Qingting Huang ¹Shikai Geng ¹Wei Hu ¹Huaiyuan Chen ¹Fangzhu Wan ¹Xingyu Liu ¹Jiyi Hu ¹Fengtao Su ²Jiade JLu ³Lin Kong¹

作者信息

1. Department of Radiation Oncology,Shanghai Proton and Heavy lon Center,Fudan University Cancer Hospital,Shanghai 201315,China Shanghai Key Laboratory of Radiation Oncology,Shanghai 201321,China Shanghai Engineering Research Center of Proton and Heavy lon Radiation Therapy,Shanghai 201321,China
2. Shanghai Key Laboratory of Radiation Oncology,Shanghai 201321,China Cancer Institute,Fudan University Shanghai Cancer Center,Shanghai Medical College of Fudan University,Shanghai,China
3. Department of Radiation Oncology,Proton and Heavy lon Center,Heyou Hospital,Foshan 523000,China
折叠

摘要

关键词

recurrent nasopharyngeal carcinoma/PARP inhibitor/radiosensitivity/cell death/autophagy

分类

医药卫生

引用本文复制引用

Ziyu Le,Haojiong Zhang,Li Chen,Wanzun Lin,Qingting Huang,Shikai Geng,Wei Hu,Huaiyuan Chen,Fangzhu Wan,Xingyu Liu,Jiyi Hu,Fengtao Su,Jiade JLu,Lin Kong..Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation[J].Acta Biochimica et Biophysica Sinica,2026,58(3):P.595-609,15.

基金项目

supported by the grants from the Natural Science Foundation of China(No.82103059) （No.82103059）

the Science and Technology Development Fund of Shanghai Pudong New Area(No.PKJ2021-Y45). （No.PKJ2021-Y45）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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