首页|期刊导航|Acta Biochimica et Biophysica Sinica|Targeting USP2 induces degradation of PML-RARαwith or without drug-resistant mutations in acute promyelocytic leukemia

Targeting USP2 induces degradation of PML-RARαwith or without drug-resistant mutations in acute promyelocytic leukemia

Jie Zhang Wenxuan Wu Yun Wang Youping Zhang Yingying Wang Wenhui Bai Zhenge Zhang Chujiao Zhu Yunzhao Wu Ziwei Zhang Li Yang Hu Lei Hanzhang Xu Li Zhou Yingli Wu

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(3)：P.574-583,10.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(3)：P.574-583,10.DOI:10.3724/abbs.2025135

Targeting USP2 induces degradation of PML-RARαwith or without drug-resistant mutations in acute promyelocytic leukemia

Jie Zhang ¹Wenxuan Wu ²Yun Wang ³Youping Zhang ²Yingying Wang ²Wenhui Bai ²Zhenge Zhang ²Chujiao Zhu ²Yunzhao Wu ⁴Ziwei Zhang ⁴Li Yang ²Hu Lei ²Hanzhang Xu ²Li Zhou ¹Yingli Wu²

作者信息

1. Shanghai Institute of Hematology,State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
2. Hongqiao International Institute of Medicine,Shanghai Tongren Hospital/Faculty of Basic Medicine,Chemical Biology Division of Shanghai Universities E-Institutes,Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
3. Shanghai Ruijin Rehabilitation Hospital,Shanghai 200023,China
4. Yusuf Hamied Department of Chemistry,University of Cambridge,Cambridge CB21EW,UK
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摘要

关键词

acute promyelocytic leukemia/PML-RARα/USP2/ML364/drug resistance

分类

医药卫生

引用本文复制引用

Jie Zhang,Wenxuan Wu,Yun Wang,Youping Zhang,Yingying Wang,Wenhui Bai,Zhenge Zhang,Chujiao Zhu,Yunzhao Wu,Ziwei Zhang,Li Yang,Hu Lei,Hanzhang Xu,Li Zhou,Yingli Wu..Targeting USP2 induces degradation of PML-RARαwith or without drug-resistant mutations in acute promyelocytic leukemia[J].Acta Biochimica et Biophysica Sinica,2026,58(3):P.574-583,10.

基金项目

supported by the grants from the National Natural Science Foundation of China(Nos.82470152,82170145,82170172) （Nos.82470152,82170145,82170172）

the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-051) （No.2019-I2M-5-051）

the Shanghai Municipal Commission of Health and Family Planning(No.ZY(2021-2023)-0208) （No.ZY(2021-2023）

the China Postdoctoral Science Foundation(No.2024M762019). （No.2024M762019）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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