Zoological Research2026，Vol.47Issue(1)：P.139-154,16.DOI:10.24272/j.issn.2095-8137.2025.044
Generation of a PKP2 heterozygous knockout pig model of arrhythmogenic cardiomyopathy
Hong-Hui Li 1Yuan Chang 2Tai-Yun Wei 3Jian-Xiong Guo 3De-Ling Jiao 4Yi-Xuan Sheng 2Hang Zhang 2Han Mo 2Pei-Yuan Li 2Hai-Zhen Wang 5Kai-Xiang Xu 4Yu-Bo Qing 4Heng Zhao 4Bao-Yu Jia 4Yan-Hua Su 4Xiao Chen 2Meng-Da Xu 2Xiu-Meng Hua 2Hao Cui 2Hao Jia 2Hong-Ye Zhao 4Jiang-Ping Song 6Hong-Jiang Wei7
作者信息
- 1. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan Agricultural University,Kunming,Yunnan 650201,China Yunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation,Kunming,Yunnan 650201,China College of Animal Science and Technology,Yunnan Agricultural University,Kunming,Yunnan 650201,China College of Veterinary Medicine,Yunnan Agricultural University,Kunming,Yunnan 650201,China
- 2. Cardiomyopathy Research Group at Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Beijing 100037,China Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials,Animal Experimental Centre,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China
- 3. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan Agricultural University,Kunming,Yunnan 650201,China Yunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation,Kunming,Yunnan 650201,China
- 4. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan Agricultural University,Kunming,Yunnan 650201,China Yunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation,Kunming,Yunnan 650201,China College of Veterinary Medicine,Yunnan Agricultural University,Kunming,Yunnan 650201,China
- 5. College of Veterinary Medicine,Yunnan Agricultural University,Kunming,Yunnan 650201,China
- 6. Cardiomyopathy Research Group at Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Beijing 100037,China Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials,Animal Experimental Centre,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China Fuwai Yunnan Hospital,Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University,Kunming,Yunnan 650102,China
- 7. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan Agricultural University,Kunming,Yunnan 650201,China Yunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation,Kunming,Yunnan 650201,China College of Veterinary Medicine,Yunnan Agricultural University,Kunming,Yunnan 650201,China Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China
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摘要
关键词
Arrhythmogenic cardiomyopathy/Pig model/BE3 gene-edit system分类
医药卫生引用本文复制引用
Hong-Hui Li,Yuan Chang,Tai-Yun Wei,Jian-Xiong Guo,De-Ling Jiao,Yi-Xuan Sheng,Hang Zhang,Han Mo,Pei-Yuan Li,Hai-Zhen Wang,Kai-Xiang Xu,Yu-Bo Qing,Heng Zhao,Bao-Yu Jia,Yan-Hua Su,Xiao Chen,Meng-Da Xu,Xiu-Meng Hua,Hao Cui,Hao Jia,Hong-Ye Zhao,Jiang-Ping Song,Hong-Jiang Wei..Generation of a PKP2 heterozygous knockout pig model of arrhythmogenic cardiomyopathy[J].Zoological Research,2026,47(1):P.139-154,16.基金项目
supported by the National Natural Science Foundation for Distinguished Young Scholars of China(82125004 to J.P.S.) （82125004 to J.P.S.）
Key Project of National Key R&D Program of the Ministry of Science and Technology of China(2023YFF0724700 to X.C.) （2023YFF0724700 to X.C.）
Major Science and Technology Project of Yunnan Province(202102AA100054) （202102AA100054）
Spring City Plan:High-level Talent Promotion and Training Project of Kunming(2022SCP001)。 （2022SCP001）
