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Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization

Changwei Li Yiming Xu Li Zhou Leilei Chang Zhou Dan Yunhe Jiang Chao Wang Lianfu Deng Guoqing Tang

Bone Research2026，Vol.14Issue(3)：P.963-980,18.

Bone Research2026，Vol.14Issue(3)：P.963-980,18.DOI:10.1038/s41413-026-00517-5

Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization

Changwei Li ¹Yiming Xu ²Li Zhou ³Leilei Chang ²Zhou Dan ²Yunhe Jiang ⁴Chao Wang ⁵Lianfu Deng ²Guoqing Tang³

作者信息

1. Department of Orthopedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China Department of Orthopedics,Kunshan Hospital of Chinese Medicine,Affiliated Hospital of Yangzhou University,Suzhou,Jiangsu Province,China Institute of Traumatology and Orthopedics,Kunshan Hospital of Chinese Medicine,Affiliated Hospital of Yangzhou University,Suzhou,Jiangsu Province,China
2. Department of Orthopedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
3. Department of Orthopedics,Kunshan Hospital of Chinese Medicine,Affiliated Hospital of Yangzhou University,Suzhou,Jiangsu Province,China Institute of Traumatology and Orthopedics,Kunshan Hospital of Chinese Medicine,Affiliated Hospital of Yangzhou University,Suzhou,Jiangsu Province,China
4. Department of Orthopedics,Kunshan Hospital of Chinese Medicine,Affiliated Hospital of Yangzhou University,Suzhou,Jiangsu Province,China
5. Department of Orthopedics,The Shanghai Tenth People’s Hospital of Tongji University,Shanghai,China
折叠

摘要

关键词

endochondral ossificationhoweverthe/mitochondrial biogenesis/chondrocyte hypertrophy/ubiquitin specific protease/endochondral ossification/skeletal developmentbone/mineralization

分类

医药卫生

引用本文复制引用

Changwei Li,Yiming Xu,Li Zhou,Leilei Chang,Zhou Dan,Yunhe Jiang,Chao Wang,Lianfu Deng,Guoqing Tang..Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization[J].Bone Research,2026,14(3):P.963-980,18.

基金项目

sponsored by National Natural Science Foundation of China(82572765,82502958,82572693,81802119,82172452,82272556,82472395,82404159) （82572765,82502958,82572693,81802119,82172452,82272556,82472395,82404159）

Shanghai Dongfang Talents Program(QNWS2024043) （QNWS2024043）

Clinical Key Disease Diagnosis and Treatment Technologies foundation of Suzhou(LCZX202340) （LCZX202340）

Traditional Chinese Medicine Science and Technology Development foundation of Jiangsu(MS2023104) （MS2023104）

Jiangsu Provincial Natural Science Foundation(BK20251831) （BK20251831）

Science and Technology Development Foundation of Suzhou(SYW2025031). （SYW2025031）

Bone Research

ISSN：2095-4700

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