|国家科技期刊平台
| 注册
首页|期刊导航|Bone Research|Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation

Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation

Luyao Wang Xiaohui Tao Hewen Jiang Shijian Ding Ning Zhang Xin Yang Shenghang Wang Yihao Zhang Nanxi Li Haitian Li Zhanghao Li Xiaoxin Wen Meiheng Sun Chuanxin Zhong Heiwa So Jin Liu Yuanyuan Yu Hua Yue Xianghang Luo Péter Ferdinandy Tao Zhang Shu Zhang Zhenlin Zhang Aiping Lu Baoting Zhang Ge Zhang

Bone Research2026，Vol.14Issue(3)：P.949-962,14.
✕
Bone Research2026，Vol.14Issue(3)：P.949-962,14.DOI:10.1038/s41413-026-00511-x

Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation

Luyao Wang 1Xiaohui Tao 1Hewen Jiang 2Shijian Ding 1Ning Zhang 2Xin Yang 1Shenghang Wang 1Yihao Zhang 1Nanxi Li 1Haitian Li 1Zhanghao Li 1Xiaoxin Wen 1Meiheng Sun 1Chuanxin Zhong 1Heiwa So 1Jin Liu 1Yuanyuan Yu 1Hua Yue 3Xianghang Luo 4Péter Ferdinandy 5Tao Zhang 6Shu Zhang 7Zhenlin Zhang 3Aiping Lu 1Baoting Zhang 2Ge Zhang1

作者信息

  • 1. Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases(TMBJ),Hong Kong Baptist University,Hong Kong SAR,China Guangdong-Hong Kong-Macao Greater Bay Area International Research Platform for Aptamer-based Translational Medicine and Drug Discovery(HKAP),Hong Kong SAR,China Institute of Integrated Bioinformedicine and Translational Science(IBTS),Hong Kong Baptist University,Hong Kong SAR,China
  • 2. School of Chinese Medicine,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
  • 3. Department of Osteoporosis and Bone Diseases,Shanghai Clinical Research Center of Bone Diseases,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China
  • 4. Xiangya Hospital of Central South University,Hu Nan,China
  • 5. Department of Pharmacology and Pharmacotherapy,Semmelweis University,Budapest,Hungary
  • 6. Shanghai Institute of Technical Physics Chinese Academy of Sciences,Shanghai,China
  • 7. The Key Laboratory of Aerospace Medicine,Ministry of Education,Air Force Medical University,Xi’an,Shanxi,China
  • 折叠

摘要

关键词

Wnt catenin signaling/osteoblastic interaction/sclerostin loop/bone formation/LRP/cardiovascular risk

分类

医药卫生

引用本文复制引用

Luyao Wang,Xiaohui Tao,Hewen Jiang,Shijian Ding,Ning Zhang,Xin Yang,Shenghang Wang,Yihao Zhang,Nanxi Li,Haitian Li,Zhanghao Li,Xiaoxin Wen,Meiheng Sun,Chuanxin Zhong,Heiwa So,Jin Liu,Yuanyuan Yu,Hua Yue,Xianghang Luo,Péter Ferdinandy,Tao Zhang,Shu Zhang,Zhenlin Zhang,Aiping Lu,Baoting Zhang,Ge Zhang..Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation[J].Bone Research,2026,14(3):P.949-962,14.

基金项目

supported by the National Key R&D Program from the Ministry of Science and Technology of China(Project No.2024YFE0216100,Project No.MHP/314/24,Project No.2018YFA0800804) （Project No.2024YFE0216100,Project No.MHP/314/24,Project No.2018YFA0800804）

Hong Kong General Research Fund from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.12102223,Project No.12102524,Project No.12100921,Project No.12100725) （Project No.12102223,Project No.12102524,Project No.12100921,Project No.12100725）

Theme-based Research Scheme from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.T12-201/20-R) （Project No.T12-201/20-R）

Young Scientists Fund of the National Natural Science Foundation of China(Grant No.82300988) （Grant No.82300988）

Shenzhen-Hong Kong-Macao Science and Technology Plan Project(Category C)(Grant No.SGDX20230821095359002) （Category C）

National Natural Science Foundation of China(Grant No.82270932) （Grant No.82270932）

Shanghai Sixth People’s Hospital High-level Talent Support Cultivation Programme Project(Project No.ynljzc202408) （Project No.ynljzc202408）

Basic and Applied Basic Research Fund from Department of Science and Technology of Guangdong Province(Project No.2019B1515120089) （Project No.2019B1515120089）

Inter-institutional Collaborative Research Scheme from Hong Kong Baptist University(Project No.RC-ICRS/19-20/01) （Project No.RC-ICRS/19-20/01）

University-Industry Collaboration Programme from Innovation and Technology Commissions of the Hong Kong Special Administrative Region,China(Project No.UIM/298) （Project No.UIM/298）

University-Industry Collaboration Programme from Innovation and Technology Commissions of the Hong Kong Special Administrative Region,China(Project No.UIM/328) （Project No.UIM/328）

Shanghai Research Center for Endocrine and Metabolic Diseases(Project No.2022ZZ01002) （Project No.2022ZZ01002）

Key Project of Research and Development Plan of Hunan Province(Project No.2022WK2010). （Project No.2022WK2010）

Bone Research

2095-4700

访问量0
|
下载量0
段落导航相关论文