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Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice

Monica Pata Diep Ngoc Thi Pham Julie Lacombe BAshok Reddy Young Woong Kim Abeer Gamal Ali Ahmed Monzur Murshed Mathieu Ferron

Bone Research2026，Vol.14Issue(3)：P.879-891,13.

Bone Research2026，Vol.14Issue(3)：P.879-891,13.DOI:10.1038/s41413-026-00528-2

Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice

Monica Pata ¹Diep Ngoc Thi Pham ¹Julie Lacombe ¹BAshok Reddy ¹Young Woong Kim ¹Abeer Gamal Ali Ahmed ²Monzur Murshed ³Mathieu Ferron⁴

作者信息

1. Molecular Physiology Research Unit,Institut de Recherches Cliniques de Montréal,Montréal,QC,Canada
2. Faculty of Dental Medicine and Oral Health Sciences,McGill University,Montréal,QC,Canada
3. Faculty of Dental Medicine and Oral Health Sciences,McGill University,Montréal,QC,Canada Department of Medicine,McGill University,Montréal,QC,Canada Shriners Hospital for Children,Montréal,QC,Canada
4. Molecular Physiology Research Unit,Institut de Recherches Cliniques de Montréal,Montréal,QC,Canada Département de Médecine,Facultéde médecine,Universitéde Montréal,Montréal,QC,Canada Division of Clinical and Translational Research,Faculty of Medicine and Health Sciences,McGill University,Montréal,QC,Canada
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摘要

关键词

glutamic acid/bone remodelingbut/osteoblasts/bone remodeling/Gas/bone resorption/osteoclasts/vitamin k

分类

医药卫生

引用本文复制引用

Monica Pata,Diep Ngoc Thi Pham,Julie Lacombe,BAshok Reddy,Young Woong Kim,Abeer Gamal Ali Ahmed,Monzur Murshed,Mathieu Ferron..Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice[J].Bone Research,2026,14(3):P.879-891,13.

基金项目

supported by funding from the Fonds de Recherche du Québec-Santé(to M.F.),Canada Research Chairs program(to M.F.) （to M.F.）

Canadian Institutes of Health Research grant PJT-159534(to M.F.).B.A.R.received a postdoctoral fellowship from the Fonds de Recherche du Québec-Santé. （to M.F.）

Bone Research

ISSN：2095-4700

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