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Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFDMAC cascade

Tongling Huang Zihui Wang Lu Gao Jun Gao Zhaocheng Lu Pengda Li Chon Him Choy Zhuolei Yuan Yanting Zhong Chang-An Geng Huaiyu Wang Kelvin W.K.Yeung Bin Li Haobo Pan Di Chen Min Guan

Bone Research2026，Vol.14Issue(3)：P.861-878,18.

Bone Research2026，Vol.14Issue(3)：P.861-878,18.DOI:10.1038/s41413-026-00527-3

Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFDMAC cascade

Tongling Huang ¹Zihui Wang ¹Lu Gao ²Jun Gao ¹Zhaocheng Lu ¹Pengda Li ¹Chon Him Choy ³Zhuolei Yuan ²Yanting Zhong ²Chang-An Geng ⁴Huaiyu Wang ⁵Kelvin W.K.Yeung ⁶Bin Li ⁷Haobo Pan ¹Di Chen ⁸Min Guan²

作者信息

1. Shenzhen Key Laboratory of Marine Biomaterials,Center for Human Tissues and Organs Degeneration,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
2. Shenzhen Key Laboratory of Marine Biomaterials,Center for Human Tissues and Organs Degeneration,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China University of Chinese Academy of Sciences,Beijing,China
3. Division of Biosciences,University College London,London,UK
4. State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,China
5. Center for AI-Driven Medical Research,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
6. Department of Orthopaedics and Traumatology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China Department of Orthopaedics and Traumatology,The University of Hong Kong-Shenzhen Hospital,Shenzhen,China
7. Medical 3D Printing Center,Orthopedic Institute,Department of Orthopedic Surgery,The First Affiliated Hospital,School of Basic Medical Sciences,Interdisciplinary Innovation Center for Nanomedicine,MOE Key Laboratory of Geriatric Diseases and Immunology,Suzhou Medical College,Soochow University,Suzhou,China
8. Center for AI-Driven Medical Research,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China Faculty of Pharmaceutical Sciences,Shenzhen University of Advanced Technology,Shenzhen,Guangdong,China
折叠

摘要

关键词

steatotic liver/cartilage damage/excessive alternative complement activationresulting/adipocyte/Osteoarthritis/Mitochondrial dysfunction/Esrra/Cfd

分类

医药卫生

引用本文复制引用

Tongling Huang,Zihui Wang,Lu Gao,Jun Gao,Zhaocheng Lu,Pengda Li,Chon Him Choy,Zhuolei Yuan,Yanting Zhong,Chang-An Geng,Huaiyu Wang,Kelvin W.K.Yeung,Bin Li,Haobo Pan,Di Chen,Min Guan..Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFDMAC cascade[J].Bone Research,2026,14(3):P.861-878,18.

基金项目

supported in part by grants from the National Key Research and Development Program of China(2023YFB3810200) （2023YFB3810200）

Shenzhen Medical Research Fund(D2301004) （D2301004）

National Natural Science Foundation of China(82372464,82072493 and 82402878) （82372464,82072493 and 82402878）

Shenzhen Science and Technology Program(JCYJ20240813154919025,JCYJ20240813154916021,SYSPG20241211173922057) （JCYJ20240813154919025,JCYJ20240813154916021,SYSPG20241211173922057）

CAS Interdisciplinary Team of“Light of West China”Program(xbzg-zdsys-202405) （xbzg-zdsys-202405）

Open Project of State Key Laboratory of Phytochemistry and Natural Medicines(P2025-KF03) （P2025-KF03）

Guangdong Basic and Applied Basic Research Foundation(2023A1515110143). （2023A1515110143）

Bone Research

ISSN：2095-4700

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