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Germinal Center–Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer

Zhihao Yin Xi Zhen Haonan Li Haiqiang Duan Xiaowei Hu Tianxi Yu Qing Shi Ziyi Liu Yaowei Li Peng Zhang Peng Dai Meihui Zhao Ziqi Wang Changfu Li Di Wang Zhichao Tong

Oncology Research2026，Vol.34Issue(7)：P.595-624,30.

Oncology Research2026，Vol.34Issue(7)：P.595-624,30.DOI:10.32604/or.2026.077808

Germinal Center–Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer

Zhihao Yin ¹Xi Zhen ²Haonan Li ¹Haiqiang Duan ¹Xiaowei Hu ³Tianxi Yu ⁴Qing Shi ⁴Ziyi Liu ⁴Yaowei Li ⁴Peng Zhang ⁴Peng Dai ⁴Meihui Zhao ⁵Ziqi Wang ⁶Changfu Li ⁷Di Wang ⁴Zhichao Tong⁸

作者信息

1. NHC Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin Medical University Cancer Hospital,Harbin Medical University,Harbin,China Department of Urology,Harbin Medical University Cancer Hospital,Harbin,China Heilongjiang Provincial Key Laboratory of Basic Medical Sciences in Urology Cancer,Harbin Medical University Cancer Hospital,Harbin,China
2. College of Life Sciences,Northeast Forestry University,Harbin,China
3. Department of Urogenital Medical Oncology,Harbin Medical University Cancer Hospital,Harbin,China
4. NHC Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin Medical University Cancer Hospital,Harbin Medical University,Harbin,China
5. Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin,China
6. NHC Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin Medical University Cancer Hospital,Harbin Medical University,Harbin,China Department of Urology,Harbin Medical University Cancer Hospital,Harbin,China Heilongjiang Provincial Key Laboratory of Basic Medical Sciences in Urology Cancer,Harbin Medical University Cancer Hospital,Harbin,China Department of Cystoscope Center,Harbin Medical University Cancer Hospital,Harbin,China
7. Department of Urology,Harbin Medical University Cancer Hospital,Harbin,China
8. NHC Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin Medical University Cancer Hospital,Harbin Medical University,Harbin,China Heilongjiang Provincial Key Laboratory of Basic Medical Sciences in Urology Cancer,Harbin Medical University Cancer Hospital,Harbin,China Department of Urogenital Medical Oncology,Harbin Medical University Cancer Hospital,Harbin,China Biobank,Harbin Medical University Cancer Hospital,Harbin,China Department of Urology,Klinikum Rechts der Isar,Technical University of Munich,Munich,Germany
折叠

摘要

关键词

Tertiary lymphoid structures/bladder cancer/germinal center(GC)–like tertiary lymphoid structure/tumor microenvironment/programmed death-ligand 1

分类

医药卫生

引用本文复制引用

Zhihao Yin,Xi Zhen,Haonan Li,Haiqiang Duan,Xiaowei Hu,Tianxi Yu,Qing Shi,Ziyi Liu,Yaowei Li,Peng Zhang,Peng Dai,Meihui Zhao,Ziqi Wang,Changfu Li,Di Wang,Zhichao Tong..Germinal Center–Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer[J].Oncology Research,2026,34(7):P.595-624,30.

基金项目

supported by Harbin Medical University Cancer Hospital Haiyan Foundation(JJZD2022-03) （JJZD2022-03）

National Natural Science Foundation of China(82573847) （82573847）

Natural Science Foundation of Heilongjiang Province of China(YQ2024H023) （YQ2024H023）

The Nn10 project at the Affiliated Cancer Hospital of Harbin Medical University(Nn102024-01) （Nn102024-01）

China&Heilongjiang Province Postdoctoral Foundation(2021M693828,LBH-Z22030) （2021M693828,LBH-Z22030）

Excellent Youth Project of Heilongjiang Provincial INatural Science Foundation(YQ2024H023) （YQ2024H023）

the Harbin Medical University Cancer Hospital Haiyan Foundation(JJZD2024-24) （JJZD2024-24）

the Harbin Medical University Cancer Hospital Haiyan Foundation(JJQN2022-07) （JJQN2022-07）

Collectively,these funding sources enabled the comprehensive execution of this study. （）

Oncology Research

ISSN：0965-0407

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