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Targeting Dynamin-Related Protein 1 and Glucose Metabolism Reverses Acquired Resistance to Sorafenib in Liver Cancer

Jinhui Che Zhiyuan Chen Feng Zhang Shuo Zhu Shengya Cao Ou Li Rong Li Jun Zheng Yubin Liu

Oncology Research2026,Vol.34Issue(7):P.497-522,26.
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Oncology Research2026,Vol.34Issue(7):P.497-522,26.DOI:10.32604/or.2026.067443

Targeting Dynamin-Related Protein 1 and Glucose Metabolism Reverses Acquired Resistance to Sorafenib in Liver Cancer

Jinhui Che 1Zhiyuan Chen 2Feng Zhang 3Shuo Zhu 4Shengya Cao 5Ou Li 2Rong Li 6Jun Zheng 3Yubin Liu2

作者信息

  • 1. Department of Hepatobiliary Surgery,Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,China Department of Hepatobiliary Surgery,Xuzhou Cancer Hospital,Xuzhou,China
  • 2. Department of Hepatobiliary Surgery,Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,China
  • 3. Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China Guangdong Key Laboratory of Liver Disease Research,Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China
  • 4. Department of Hepatobiliary Surgery,Xuzhou Cancer Hospital,Xuzhou,China
  • 5. Department of Clinical Laboratory,Xuzhou Cancer Hospital,Xuzhou,China
  • 6. Guangdong Key Laboratory of Liver Disease Research,Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China
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摘要

关键词

Sorafenib-resistant hepatocellular carcinoma/mitochondrial dynamics/glucose metabolism/mdivi-1/IACS-010759

分类

医药卫生

引用本文复制引用

Jinhui Che,Zhiyuan Chen,Feng Zhang,Shuo Zhu,Shengya Cao,Ou Li,Rong Li,Jun Zheng,Yubin Liu..Targeting Dynamin-Related Protein 1 and Glucose Metabolism Reverses Acquired Resistance to Sorafenib in Liver Cancer[J].Oncology Research,2026,34(7):P.497-522,26.

基金项目

supported by the Natural Science Foundation of Guangdong Province(1914050004928) (1914050004928)

the Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission(XWKYSL20220353). (XWKYSL20220353)

Oncology Research

0965-0407

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