广东医学2026，Vol.47Issue(6)：816-820,5.DOI:10.13820/j.cnki.gdyx.20261354
年轻乳腺癌患者生育力保存及辅助生殖38例
Fertility preservation and assisted reproductive outcomes in young women with breast cancer:a retrospective study
摘要
Abstract
Objective To study the effectiveness of fertility preservation and assisted reproduction in young breast cancer patients.Methods Clinical data from 38 young breast cancer patients undergoing fertility preservation(oocyte cry opreservation or embryo cry opreservation)and assisted reproduction at the Reproductive Medicine Center of Sun Yat-sen Memorial Hospital between 2010 and December 2024 were retrospectively analyzed,involving a total of 53 cycles.Pa-tients undergoing IVF/ICSI treatment due to tubal or male factors served as the control group.Ovarian stimulation out-comes and assisted reproductive outcomes were compared between the two groups.Results There were no significant differences between the breast cancer group and the control group in the number of retrieved oocytes,mature oocytes,available embryos,high-quality embryos,blastocyst formation number,or blastocyst formation rate.However,the high-quality embryo rate was significantly lower in the breast cancer group than in the control group(23.36％vs.39.09％,P=0.010).Comparable ovarian stimulation outcomes were observed between the luteal-phase long protocol and antago-nist protocol.In addition,no statistically significant differences were found in estradiol levels on trigger day,number of re-trieved oocytes,or mature oocyte count between subgroups receiving letrozole supplementation at doses of 2.5 mg/day and 5 mg/day during ovarian stimulation.Seven patients completed breast cancer treatment and subsequently underwent assis-ted reproductive treatment.Among five fresh embryo transfer cycles,three resulted in full-term live births.Among six frozen-thawed embryo transfer cycles,including one patient carrying a BRCA2 mutation who underwent preimplantation genetic testing,three resulted in full-term live births and one resulted in early miscarriage.Conclusion Assisted repro-ductive technology provides effective options for fertility preservation and infertility treatment in young patients with breast cancer.关键词
年轻乳腺癌患者/生育力保存/卵巢功能减退/辅助生殖技术Key words
young breast cancer patients/fertility preservation/diminished ovarian reserve/assisted reproduc-tive technology分类
医药卫生引用本文复制引用
龙俊翔,刘强,张清学,梁怡婳,焦雪丹,谢言信,邱绮,林海燕,杨茜,冀晓慧,陈慧..年轻乳腺癌患者生育力保存及辅助生殖38例[J].广东医学,2026,47(6):816-820,5.基金项目
国家自然科学基金资助项目(82171642) （82171642）
中山大学临床医学研究5010计划项目(2016004) （2016004）
