广东医学2026，Vol.47Issue(6)：857-862,6.DOI:10.13820/j.cnki.gdyx.20253373
血清MMP11和TGF-β1在前列腺癌病理分期及预后评估中的应用
Clinical application of serum MMP11 and TGF-β1 in pathological staging and prognosis evaluation of prostate cancer
摘要
Abstract
Objective To evaluate the expression patterns of serum matrix metalloproteinase 11(MMP11)and transforming growth factor β1(TGF-β1)in prostate cancer(PCa)patients and their associations with pathological stag-ing and prognosis,and to investigate the prognostic predictive value of their combined assessment.Methods A total of 116 patients with histologically confirmed PCa were enrolled.Serum levels of MMP11 and TGF-β1 were measured at di-agnosis.Comparisons were made between PCa patients and benign prostatic hyperplasia(BPH)controls.Patients were stratified into high-and low-expression groups based on the median serum levels of MMP11 and TGF-β1.Associa-tions with clinicopathological features were analyzed.Kaplan-Meier survival curves and Cox proportional hazards models were applied to identify independent prognostic factors.Receiver operating characteristic(ROC)curves were plotted to as-sess the predictive performance of MMP11,TGF-β1,and their combination.Results Serum MMP11 and TGF-β1 levels were significantly elevated in PCa patients compared with BPH controls(P＜0.05),and increased progressively with advancing TNM stage(P＜0.05).High MMP11 expression was associated with unfavorable clinicopathological fea-tures,including higher PSA and CRP levels,advanced clinical stage,increased lymph node metastasis,and larger tumor diameter(all P＜0.05).High TGF-β1 expression showed a similar adverse profile.Kaplan-Meier analysis demonstra-ted significantly lower overall survival in patients with high MMP11 or TGF-β1 expression.Multivariate Cox analysis con-firmed that high MMP11(HR=3.723)and high TGF-β1(HR=2.692)were independent predictors of poor prognosis after adjusting for TNM stage,lymph node metastasis,and PSA.ROC analysis showed that the area under the curve(AUC)for MMP11,TGF-β1,and their combination in predicting prognosis were 0.715,0.704,and 0.783,respec-tively.Conclusion Serum MMP11 and TGF-β1 levels are significantly elevated in PCa patients and increase with dis-ease stage.Their high expression is associated with adverse clinicopathological characteristics and poor survival,and both serve as independent prognostic indicators.Combined assessment of MMP11 and TGF-β1 enhances prognostic discrimi-nation in PCa,offering potential clinical utility.关键词
前列腺癌/基质金属蛋白酶/转化生长因子β1/病理分期/预后Key words
prostate cancer/matrix metalloproteinase 11/transforming growth factor β1/pathological staging/prognosis分类
医药卫生引用本文复制引用
刘俊志,陈佳韬,陈建刚,朱华,徐鑫,张勇,李孝艺,葛培培,沈城,姜浩,胡德华,刘建炜..血清MMP11和TGF-β1在前列腺癌病理分期及预后评估中的应用[J].广东医学,2026,47(6):857-862,6.基金项目
湖南省重点领域研发计划(国际与区域合作)(2021WK2003) （国际与区域合作）
湖南省自然科学基金面上项目(2025JJ50542) （2025JJ50542）
南通市科技计划项目(MSZ2024099) （MSZ2024099）
南通市卫生健康委员会科研课题专项(MS2024032) （MS2024032）
南通大学临床医学专项科研基金项目(2024LY006,2024LQ019) （2024LY006,2024LQ019）
神州药动学——南通大学2024年科研能力建设基金项目(2024-KY002-01) （2024-KY002-01）
