国际老年医学杂志2026，Vol.47Issue(4)：404-410,7.DOI:10.3969/j.issn.1674-7593.2026.04.002
老年原发性高血压患者内皮祖细胞与动脉硬化的关系
The relationship between endothelial progenitor cells and arteriosclerosis in elderly patients with essential hypertension
摘要
Abstract
Objective To investigate the correlation between peripheral blood endothelial progenitor cells(EPCs)and arte-riosclerosis in elderly patients with essential hypertension.Methods A total of 340 elderly patients aged 60 years and above diagnosed with essential hypertension,who visited the Health Management Center and Department of Geriatrics at Inner Mongolia Autonomous Re-gion People's Hospital from July 2024 to July 2025,were enrolled as study subjects.Patients were stratified into four groups(Q1-Q4)based on EPCs quartile levels,comprising 85,85,83,and 87 cases,respectively;multivariable linear regression models were con-structed to investigate the linear relationships between various factors and arteriosclerosis/arterial stiffness.The robustness of the associ-ation was further assessed through subgroup analyses stratified by history of smoking,alcohol consumption,diabetes,and body mass index(BMI)levels(BMI≥28 kg/m2 vs.<28 kg/m2).Meanwhile,receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of EPCs for arteriosclerosis in elderly patients with essential hypertension.Results Among elderly pa-tients with essential hypertension,there were statistically significant differences(P<0.05)in age,gender,smoking history,drinking history,diabetes history,systolic blood pressure(SBP),diastolic blood pressure(DBP),brachial-ankle pulse wave velocity(baP-WV),heart rate(HR),mean arterial pressure(MAP),high-sensitivity C-reactive protein(hs-CRP),triglycerides(TG),total cholesterol(TC),and fasting blood glucose(FBG)across groups with different levels of endothelial progenitor cells(EPCs).Multi-variate linear regression analysis showed that history of diabetes and SBP were independent risk factors for the degree of arteriosclerosis in elderly patients with essential hypertension,while EPCs were a protective factor.Subgroup analysis indicated that EPCs were nega-tively correlated with baPWV(P<0.05).The area under the ROC curve for EPCs in predicting arteriosclerosis in elderly patients with essential hypertension was 0.883,demonstrating a higher predictive value compared to SBP.Conclusion Circulating CD34+CD309+double-positive EPCs in peripheral blood are negatively correlated with baPWV and may serve as a potential biomarker for predicting arterial stiffness in elderly patients with essential hypertension.关键词
原发性高血压/内皮祖细胞/动脉硬化/臂踝脉搏波传导速度Key words
Essential hypertension/Endothelial progenitor cells/Arteriosclerosis/Brachial-ankle pulse wave velocity引用本文复制引用
李卫红,邬倩,李树斌,孙于欣,李红,格日乐其其格,邬真力..老年原发性高血压患者内皮祖细胞与动脉硬化的关系[J].国际老年医学杂志,2026,47(4):404-410,7.基金项目
国家自然科学基金资助项目(82360285) （82360285）
