国际老年医学杂志2026，Vol.47Issue(4)：418-425,8.DOI:10.3969/j.issn.1674-7593.2026.04.004
焦虑在老年肺癌患者认知功能与肌少症间的中介作用
The mediation role of anxiety in elderly lung cancer patients between cognitive function and sarcopenia
摘要
Abstract
Objective To investigate the mediation role of anxiety in the relationship between cognitive function and sar-copenia in elderly lung cancer patients,providing a theoretical basis for clinical interventions in this population.Methods A retro-spective study was conducted involving 258 elderly lung cancer patients from Karamay Central Hospital from October 2022 to January 2025.Participants were assessed using a demographic questionnaire,the Mini-Mental State Examination(MMSE),and the General-ized Anxiety Disorder-7(GAD-7)scale.Data analysis employed Spearman's rank correlation analysis and the PROCESS procedure to evaluate mediation effects.Results The prevalence of sarcopenia among elderly lung cancer patients was 43.8%.Spearman's correla-tion coefficient revealed a significant negative correlation between cognitive function and anxiety(r=-0.869,P<0.001),and a signif-icant positive correlation between anxiety and sarcopenia(r=0.560,P<0.001).Mediation effect analysis revealed no direct associa-tion between cognitive function and sarcopenia(B=-0.053,P=0.271).Anxiety exerted a significant mediation effect between cogni-tive function and sarcopenia(indirect effect a×b=-0.176,95%CI:-0.277 to-0.095;Here,a×b represents the indirect effect val-ue,reflecting the strength of cognitive function's influence on sarcopenia through anxiety).Conclusion Anxiety plays a significant mediation role between cognitive function and sarcopenia in elderly lung cancer patients.Clinical management should prioritize mental health interventions to enhance overall health outcomes in this population.关键词
肺癌/肌少症/焦虑/认知功能/中介效应Key words
Lung cancer/Sarcopenia/Anxiety/Cognitive function/Mediation effect引用本文复制引用
唐萍,周亮,李砥,李松达,姚雪梅..焦虑在老年肺癌患者认知功能与肌少症间的中介作用[J].国际老年医学杂志,2026,47(4):418-425,8.基金项目
天山英才医药卫生高层次人才培养计划(TSYC202301B150) （TSYC202301B150）
新疆维吾尔自治区自然科学基金(2024D01C131) （2024D01C131）
