国际老年医学杂志2026，Vol.47Issue(4)：434-445,12.DOI:10.3969/j.issn.1674-7593.2026.04.006
牙周炎通过DAGK调控ERK1/2-NF-κB信号通路加重心肌梗死的机制研究
The exacerbation of myocardial infarction by periodontitis involves DAGK-mediated modulation of the ERK1/2-NF-κB signaling pathway
丁瞳 1费鸿博1
作者信息
- 1. 吉林大学口腔医院,吉林 长春 130021
- 折叠
摘要
Abstract
Objective To investigate the causal relationship between periodontitis and myocardial infarction and to elucidate the underlying molecular mechanisms.Methods A two-sample Mendelian randomization analysis was employed to assess the causal association between periodontitis and myocardial infarction,combined with bioinformatics analysis to screen for potential therapeutic tar-gets.In vivo validation was conducted using established animal models,utilizing techniques such as micro-CT,histological staining,immunofluorescence staining,echocardiography,and electrocardiography.Results The Mendelian randomization analysis demonstra-ted a significant positive correlation between periodontitis and the risk of myocardial infarction.Mechanistic investigations revealed that periodontitis exacerbates post-myocardial infarction pathological injury via the activation of the diacylglycerol kinase-mediated extracel-lular signal-regulated kinase1/2-nuclear factor κB(ERK1/2-NF-κB)signaling pathway.Conclusion Periodontitis serves as a risk factor for myocardial infarction,with mechanisms potentially involving the diacylglycerol kinase-regulated ERK1/2-NF-κB signaling pathway.These findings provide effective strategies for improving the prognosis of myocardial infarction patients with comorbid peri-odontitis and mitigating adverse ventricular remodeling.关键词
牙周炎/心肌梗死/孟德尔随机化分析/生信分析/细胞外信号调节激酶1/2-核因子-κB信号通路Key words
Periodontitis/Myocardial infarction/Mendelian randomization analysis/Bioinformatics analysis/Extracellular signal-regulated kinase1/2-nuclear factor kappa-B signaling pathway引用本文复制引用
丁瞳,费鸿博..牙周炎通过DAGK调控ERK1/2-NF-κB信号通路加重心肌梗死的机制研究[J].国际老年医学杂志,2026,47(4):434-445,12.
