国际老年医学杂志2026，Vol.47Issue(4)：446-452,7.DOI:10.3969/j.issn.1674-7593.2026.04.007
乳腺癌HER2基因扩增与临床病理参数的对比分析
Comparison of HER2 gene amplification and clinic opathological parameters in breast cancer
摘要
Abstract
Objective To investigate the relationship between HER2 gene amplification status and various clinicopathologi-cal parameters in breast cancer,and to provide a scientific basis for risk prediction of recurrence and metastasis as well as precision tar-geted therapy for breast cancer.Methods A retrospective analysis was conducted on 205 breast cancer patients with human epidermal growth factor receptor 2(HER2)immunohistochemistry(IHC)2+(equivocal)results admitted to Changchun Cancer Hospital from April 2020 to June 2024.Fluorescence in situ hybridization(FISH)was used to detect HER2 gene amplification.The associations be-tween different HER2 amplification statuses and age,tumor diameter,TNM stage,pathological grade,lymph node metastasis,estrogen receptor(ER)/progesterone receptor(PR)expression,and proliferative marker antigen(Ki-67)expression were compared.Fur-thermore,the relationship between HER2 amplification and lymph node metastasis was explored in depth according to different age groups(using 55 years as cut-off),tumor diameters(using 3 cm as cut-off),and Ki-67 expression levels(using 50%as cut-off),with a focus on analyzing the differences in clinicopathological parameters associated with HER2 amplification across different age strati-fications.Results Among the 205 patients,44(21.5%)were positive for HER2 gene amplification.HER2 amplification status was significantly associated with TNM stage,tumor diameter,Ki-67 expression,and ER/PR expression(all P<0.05).Lymph node me-tastasis was significantly associated with age,tumor diameter,and Ki-67 expression(all P<0.05).In patients aged<55 years,the lymph node metastasis rate was significantly higher in the HER2 amplification-positive group than in the negative group(P<0.05).After stratification by tumor diameter and Ki-67 expression,statistically significant differences in TNM stage and lymph node metastasis rate were observed between different age groups(all P<0.05).Conclusion HER2 gene amplification in breast cancer is associated with multiple clinicopathological parameters,and its impact on the risk of lymph node metastasis is age-dependent,with a more pro-nounced risk observed in younger patients.These findings provide a scientific basis and feasibility for improving the precise assessment of recurrence and metastasis risk and for individualized precision medicine in breast cancer.关键词
乳腺癌/荧光原位杂交/HER2基因扩增/临床病理参数Key words
Breast cancer/Fluorescence in situ hybridization/HER2 gene amplification/Clinical pathological parameters引用本文复制引用
艾东晴,张桂珍,秦续元,孙世豪,杜珍武,张闻铄..乳腺癌HER2基因扩增与临床病理参数的对比分析[J].国际老年医学杂志,2026,47(4):446-452,7.基金项目
吉林省科学技术厅项目(YDZJ202201ZYTS127) （YDZJ202201ZYTS127）
吉林省发展和改革委员会项目(2023C041-6、2023C011) （2023C041-6、2023C011）
吉林省卫生厅项目(2024A036) （2024A036）
