国际妇产科学杂志2026，Vol.53Issue(3)：241-248,8.DOI:10.12280/gjfckx.20251239
趋化因子及其受体在子痫前期发病机制中的作用
The Role of Chemokines and Their Receptors in the Pathogenesis of Preeclampsia
曹茹 1何碧薇 2杨星宇 2梁淑贞 1程蔚蔚2
作者信息
- 1. 200030 上海交通大学医学院附属国际和平妇幼保健院中心实验室||上海市胚胎源性疾病重点实验室
- 2. 200030 上海交通大学医学院附属国际和平妇幼保健院中心实验室
- 折叠
摘要
Abstract
Preeclampsia(PE)is a severe and highly prevalent pregnancy complication with a complex pathogenesis involving multiple pathological processes.Studies have demonstrated that the expression levels and functions of certain specific chemokines and their receptors are significantly different between pregnant women with PE and normal pregnant women.These abnormalities can be cooperatively regulated through multiple signaling pathways,disrupting the immune tolerance homeostasis at the maternal-fetal interface and inducing local immune microenvironment disturbances.Simultaneously,they interfere with normal placental vascular development and remodeling,and significantly inhibit the migration,invasion and infiltration capabilities of trophoblast cells.Consequently,they contribute to impaired spiral artery remodeling,placental hypoperfusion and ischemic-hypoxic injury,excessive activation of systemic inflammatory responses,and vascular endothelial dysfunction,ultimately participating in and mediating the onset and progression of PE.This review summarizes recent research advances regarding the role of chemokines and their receptors in the pathogenesis of PE,aiming to provide a theoretical basis and new insights for the diagnosis and treatment of PE.关键词
炎症趋化因子类/受体,趋化因子/先兆子痫/母胎界面/免疫调节Key words
Inflammatory chemokines/Receptors,chemokine/Pre-eclampsia/Maternal-fetal interface/Immune regulation引用本文复制引用
曹茹,何碧薇,杨星宇,梁淑贞,程蔚蔚..趋化因子及其受体在子痫前期发病机制中的作用[J].国际妇产科学杂志,2026,53(3):241-248,8.
