国际妇产科学杂志2026，Vol.53Issue(3)：249-254,6.DOI:10.12280/gjfckx.20260100
皮质类固醇在双胎妊娠晚期早产中应用的研究进展
Research Progress on the Application of Corticosteroids in Late Preterm Twin Pregnancies
摘要
Abstract
The preterm birth rate in twin pregnancies is 47.6%-69.0%,with the late preterm birth rate ranging from 33.0%to 59.8%,which is significantly higher than in singleton pregnancies.The use of antenatal corticosteroids(ACS)before 34 weeks of gestation can effectively reduce complications such as neonatal mortality,but its application in late preterm birth is controversial,especially in twin pregnancies.Most studies support that ACS can reduce respiratory complications such as respiratory distress syndrome in late preterm neonates from twin pregnancies.However,some studies find no clear association between them,and the effect is inferior to that in singleton pregnancies.The long-term impact of ACS on the neurological development of late preterm infants from twin pregnancies is not yet clear.Some evidence suggests a possible increased risk of cognitive developmental delays,attention deficits,and hyperactivity disorders.Animal experiments have also verified the potential neuroinjury mechanisms of ACS.Concurrently,ACS may increase the risk of hypoglycemia in late preterm infants from twin pregnancies,and hypoglycemia also has a potential association with long-term neurodevelopmental abnormalities.Currently,there is a lack of consensus in both domestic and international guidelines regarding the routine use of ACS in late preterm twin pregnancies,with most recommending individualized decision-making.关键词
妊娠,双胎/婴儿,早产/晚期早产/肾上腺皮质激素类/呼吸系统/低血糖症/神经系统Key words
Pregnancy,twin/Infant,Premature/Late preterm birth/Adrenal cortex hormones/Respiratory system/Hypoglycemia/Nervous system引用本文复制引用
娄颖亚,高娟妹,翟洪波..皮质类固醇在双胎妊娠晚期早产中应用的研究进展[J].国际妇产科学杂志,2026,53(3):249-254,6.基金项目
浙江省医药卫生科技计划项目(2025KY1076) （2025KY1076）
