国际妇产科学杂志2026，Vol.53Issue(3)：278-284,7.DOI:10.12280/gjfckx.20251474
PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展
Research Progress on Dual-Gene Methylation Testing of PAX1/JAM3 in Management of Cervical Lesion
摘要
Abstract
The application value of epigenetic biomarkers in the precision screening of cervical cancer is becoming increasingly prominent.Among these,the aberrant methylation of paired box gene 1(PAX1)and junctional adhesion molecule 3(JAM3)serves as a key epigenetic event during the malignant transformation of host cells.It can objectively reflect the abnormal transformation state of cervical epithelial cells,establishing itself as a biomarker for the early diagnosis of cervical cancer.PAX1 exerts tumor-suppressive role by inhibiting multiple carcinogenic pathways such as Wnt/β-catenin,and its methylation is a sensitive indicator in the early stages of carcinogenesis.JAM3 is closely related to epithelial barrier function and tumor invasion and metastasis,with its methylation level significantly increasing with disease progression.The combined methylation testing of these two genes exhibits high sensitivity and specificity,significantly outperforming traditional cytological methods.It not only enables precise and early identification but also effectively triages individuals who test positive in primary HPV screening,reducing unnecessary referrals for colposcopy.Furthermore,this test is applicable to the"self-sampling"mode,which helps improve screening accessibility in primary care and resource-limited settings.Additionally,combined PAX1/JAM3 methylation testing can predict the risk of pathological upgrading after cervical conization,guiding individualized therapeutic decisions.In the future,multi-center,large-sample clinical studies are needed to further establish standardized cut-off values for PAX1/JAM3 methylation.This combined testing is expected to be integrated as a core technology into cervical cancer screening guidelines,promoting a major shift in cervical cancer screening from"population-based screening"to a model of"individualized precision prevention and control."关键词
配对盒基因1/连接黏附分子3/甲基化/宫颈肿瘤/癌/癌症早期检测Key words
Paired box gene 1/Junctional adhesion molecule 3/Methylation/Uterine cervical neoplasms/Carcinoma/Early detection of cancer引用本文复制引用
何倩楠,黄子杰,王一帆,安雨声,冯淑娴..PAX1/JAM3双基因联合甲基化检测在宫颈病变管理中的研究进展[J].国际妇产科学杂志,2026,53(3):278-284,7.基金项目
兰州科技计划项目(2025-5-239) （2025-5-239）
