保健医学研究与实践2026，Vol.23Issue(4)：30-35,6.DOI:10.11986/j.issn.1673-873X.2026.04.05
基于网络毒理学与分子对接解析PBDEs致妊娠期SCH合并血脂异常、贫血的潜在毒性机制
Exploring the potential toxic mechanisms of PBDEs-induced gestational SCH complicated with dyslipidemia and anemia based on network toxicology and molecular docking
摘要
Abstract
Objective To explore the potential toxic mechanisms of polybrominated diphenyl ethers(PBDEs)-induced gesta-tional subclinical hypothyroidism(SCH)complicated with dyslipidemia and anemia based on network toxicology and molecu-lar docking,so as to provide a reference for clinical treatment.Methods By searching databases such as OMIM and Gene-Cards,disease-related genes for SCH,dyslipidemia,and anemia were collected,and potential targets for these three disea-ses were screened.R software(version 4.4.3)was used for Gene Ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis of the intersecting targets.A proteinprotein in-teraction(PPI)network was constructed based on the STRING database,and core targets were screened.Molecular docking validation was performed using AutoDock Vina 1.1.2.A regulatory interaction network of"thyroid hormone-lipid metabo-lism-pregnancy complications"was constructed to predict key signaling pathways involved in the study.Results TP53 was identified as the core target of PBDEs'effects on the"thyroid hormone-lipid metabolism-pregnancy complications"interac-tion network.Molecular docking results showed that the binding energy of the PBDEs-TP53 complex was-5.56 kcal/mol,indicating strong affinity.Conclusion PBDEs may disrupt the homeostasis of the"thyroid-lipid metabolism-anemia"inter-action network by targeting TP53 and activating inflammatory pathways,thereby exacerbating the risk of metabolicimmune imbalance during pregnancy.For pregnant women with gestational SCH complicated with dyslipidemia,reducing environ-mental exposure to PBDEs and implementing targeted interventions around inflammationrelated pathways may serve as novel prevention and treatment strategies to improve pregnancy outcomes in this population.关键词
妊娠期亚临床甲状腺功能减退症/多溴联苯醚/交互网络/网络毒理学Key words
Gestational subclinical hypothyroidism/Polybrominated diphenyl ethers/Interaction network/Network toxicology分类
医药卫生引用本文复制引用
颜楚麟,牛强,肖梦欢,丁雪漫,刘丽,王奎,宋晓钰,申冰洁,习丽娟,马娇龙..基于网络毒理学与分子对接解析PBDEs致妊娠期SCH合并血脂异常、贫血的潜在毒性机制[J].保健医学研究与实践,2026,23(4):30-35,6.基金项目
国家自然科学基金项目(82360671) （82360671）
兵团科技计划项目(2025DB010、2025DB047) （2025DB010、2025DB047）
兵团引导类科技计划项目(2024ZD025、2025ZD012) （2024ZD025、2025ZD012）
石河子大学高层次人才科研启动项目(RCZK202368) （RCZK202368）
石河子大学国际科技合作促进计划项目(GJHZ202308). （GJHZ202308）
