军事医学2026，Vol.50Issue(6)：408-416,9.DOI:10.7644/j.issn.1674-9960.2026-00004
基底前脑Oxtr+神经元在慢性社交挫败应激中的功能研究
Functional investigation of Oxtr+ neurons in the basal forebrain during chronic social defeat stress
摘要
Abstract
Objective To investigate the regulatory role of oxytocin receptors(Oxtr)in the basal forebrain in chronic social defeat stress(CSDS)-induced social avoidance behavior.Methods c-Fos immunofluorescence staining,stereotaxic injection,fiber photometry calcium recording,and RNAscope in situ hybridization were employed to compare behavioral performance and neural activity between wild-type mice and those with basal forebrain-specific Oxtr deletion under the CSDS model.Results Compared with the control group without CSDS exposure,CSDS-exposed mice had their social interactions with unfamiliar CD1 mice significantly shortened,accompanied by a marked increase in the proportion of c-Fos-positive neurons in the basal forebrain.Fiber photometry recordings suggested that calcium activity in Oxtr+ neurons of the basal forebrain was significantly enhanced during social interactions in CSDS mice.Notably,selective deletion of Oxtr in the basal forebrain significantly alleviated CSDS-induced social avoidance and effectively attenuated stress-induced neuronal hyperactivation.Conclusion Basal forebrain Oxtr+neurons play a key regulatory role in chronic social defeat stress-induced social avoidance and the processing of social fear-related cues.关键词
基底前脑/催产素受体/慢性社交挫败应激/社交回避/社交恐惧Key words
basal forebrain/oxytocin receptor/chronic social defeat stress/social avoidance/social fear分类
生物科学引用本文复制引用
宁书艺,李灏,李燊,杨睿,余燕,吴海涛..基底前脑Oxtr+神经元在慢性社交挫败应激中的功能研究[J].军事医学,2026,50(6):408-416,9.基金项目
国家自然科学基金面上项目(32171148) （32171148）
国家自然科学基金杰出青年科学基金项目(32325025) （32325025）
