军事医学2026，Vol.50Issue(6)：417-424,8.DOI:10.7644/j.issn.1674-9960.2026-00043
音乐在运动抗抑郁中的协同作用及机制研究
Synergistic effects of music and exercise for antidepression and mecha-nisms
摘要
Abstract
Objective To explore the synergistic antidepressant effects of music therapy combined with exercise and to elucidate the underlying mechanisms.Methods A depressive-like mouse model was established using the chronic restraint stress(CRS)paradigm.The effects of exercise alone and exercise combined with music were assessed.Behavioral alterations were evaluated using the elevated plus maze and forced swim tests.Hippocampal transcriptomic sequencing was performed to investigate potential molecular mechanisms by which music enhanced the antidepressant efficacy of exercise.Microglial activation was examined via immunofluorescence staining.Systemic inflammatory changes were quantified using RT-qPCR.Neuronal injury and synaptic plasticity were assessed using Nissl staining and Golgi staining,respectively.Results Behavioral assessments showed that CRS induced distinct depressive-like behaviors,which were reversed by exercise and improved by the combined music-exercise intervention.Transcriptomic analysis suggested that music could enhance the antidepressant effects of exercise by modulating neuroinflammatory pathways.Immunofluorescence and RT-qPCR results indicated that the combined intervention could more significantly reduce levels of peripheral inflammatory cytokines and ameliorate systemic inflammation than exercise alone.Nissl and Golgi staining revealed that music combined with exercise more effectively mitigated depression-related neuronal damage,as evidenced by increased Nissl body abundance and enhanced dendritic spine density in the hippocampus.Conclusion The combination of music and exercise can more effectively improve depressive-like behaviors in CRS mice than exercise alone.This enhanced benefit may be associated with attenuation of neuroinflammation and improved recovery of neuronal integrity and synaptic plasticity.关键词
音乐治疗/运动/抑郁/神经炎症Key words
music therapy/exercise/depression/neuroinflammation分类
医药卫生引用本文复制引用
陈隽睿,杜春晓,路佳文,李宇翔,王智鼎,李葛,韩根成..音乐在运动抗抑郁中的协同作用及机制研究[J].军事医学,2026,50(6):417-424,8.基金项目
国家自然科学基金项目(82371776) （82371776）
