军事医学2026，Vol.50Issue(6)：467-473,7.DOI:10.7644/j.issn.1674-9960.2025-00231
吸入制剂相关辅料种类及研究进展
Advancements in research on types of excipients of inhaled preparations
苗盼雨 1邓耀辰 2李聪慧 3张慧 3王增明 3郑爱萍 1刘楠3
作者信息
- 1. 华北理工大学,河北 唐山 063210||军事科学院军事医学研究院,北京 100850
- 2. 马来亚大学,吉隆坡 50603
- 3. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
Abstract
Pharmaceutical excipients are critical to the performance and safety of pulmonary inhaled formulations.This article reviews the research advances in key excipients of three dominating types of inhaled preparations:pressurized metered-dose inhalers,nebulizers,and dry powder inhalers.The first type contains propellants(becoming novel and environmentally friendly)that serve as the driving force,cosolvents/solubilizers(e.g.,ethanol)that enhance drug solubility,and stabilizers(e.g.,surfactants,antioxidants)that maintain physical and chemical stability.The second type-nebulizers-are solutions or suspension systems that rely on appropriate cosolvents and stabilizers to ensure the solubility,sterility and stability of drugs.Finally,dry powder inhalers,which require no propellants,depend on the properties of carrier excipients(e.g.,lactose),the use of dispersion enhancers(e.g.,L-leucine),and stabilizer systems to ensure stability of products.The research and development of excipients will become increasingly functional and intelligent.Advances in novel nano-excipients and nucleic acid delivery systems are expected to provide new solutions to the pulmonary delivery of macromolecular drugs.关键词
肺吸入制剂/药用辅料/吸入气雾剂/吸入喷雾剂/吸入粉雾剂Key words
pulmonary inhalation formulations/pharmaceutical excipients/pressurized metered-dose inhalers/nebulizers/dry powder inhalers分类
医药卫生引用本文复制引用
苗盼雨,邓耀辰,李聪慧,张慧,王增明,郑爱萍,刘楠..吸入制剂相关辅料种类及研究进展[J].军事医学,2026,50(6):467-473,7.
